Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/666
Título: Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice
Autor: Morgado, Manuel
Rolo, Sandra
Macedo, Ana Filipa
Sousa, Miguel Castelo-Branco Craveiro
Palavras-chave: Antihypertensives
Blood pressure
Data: Jan-2011
Editora: Peng Zhou
Relatório da Série N.º: Vol 2 / Issue 1 / Jan-Mar 2011;
Resumo: Background: Some clinical evidence revealed that statins, apart from lowering cholesterol levels, also have an antihypertensive effect. Our aim was to evaluate the existence of a possible association of statin therapy with blood pressure (BP) control in clinical practice. Materials and Methods: Patients attending a hypertension/ dyslipidemia clinic were prospectively evaluated. Those patients with a diagnosis of stage 1 hypertension and hypercholesterolemia who consented to participate were included in the study, either in the statin group (when taking a statin) or in the control group (when not taking a statin). Exclusion criteria included dementia, pregnancy, or breastfeeding, and history or evidence of stage 2 hypertension. Detailed clinical information was prospectively obtained from medical records. A total of 110 hypertensive patients were assigned to the study (82 in the statin group and 28 in the control group). Results: Although there were no signifcant differences (P > 0.05) in both groups concerning gender, body mass index, antihypertensive pharmacotherapy, and serum levels of high-density lipoprotein cholesterol and triglycerides, a higher BP control was observed in the statin group (P = 0.002). Signifcantly lower systolic BP (−6.7 mmHg, P = 0.020) and diastolic BP (−6.4 mmHg, P = 0.002) levels were reported in the statin group. Serum levels of low-density lipoprotein were also signifcantly lower in the statin group (P < 0.001). Conclusions: This observational study detected an association of statin therapy with BP control in hypertensive hypercholesterolemic patients in clinical practice. These fndings raise the possibility that statin therapy may be useful for BP control in the studied population.
Peer review: yes
URI: http://hdl.handle.net/10400.6/666
ISSN: 0975-3583
Versão do Editor: http://www.jcdronline.com/temp/JCardiovascDisRes2144-612623_170102.pdf
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