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- Concepts for the Development of Person-Centered, Digitally Enabled, Artificial IntelligenceāAssisted ARIA Care Pathways (ARIA 2024)Publication . Bousquet, Jean; SchĆ¼nemann, Holger; Sousa-Pinto, Bernardo; Zuberbier, Torsten; Togias, Alkis; SamoliÅski, BolesÅaw; Bedbrook, Anna; Czarlewski, Wienczyslawa; Hofmann-Apitius, Martin; Litynska, Justyna; Vieira, Rafael JosĆ©; Giuliano, Antonio F.M.; Gotua, Maia; Gradauskiene, Brigita; Guzman, Maria Antonieta; Hossny, Elham; HrubiÅ”ko, Martin; Iinuma, Tomohisa; Irani, Carla; Ispayeva, Zhanat; Ivancevich, Juan Carlos; Anto, Josep M.; Jartti, Tuomas; Jesenak, Milos; Julge, Kaja; Jutel, Marek; Kaidashev, Igor; Bennoor, Kazi Saifuddin; Khaltaev, Nicolai; Kirenga, Bruce; Kraxner, Helga; Kull, Inger; Fonseca, Joao A; Kulus, Marek; Kuna, Piotr; Kupczyk, Maciej; Kurchenko, Andriy; La Grutta, Stefania; Lane, Stephen; Miculinic, Neven; Lee, Sang Min; Le Thi Tuyet, Lan; Lkhagvaa, Battur; Brozek, Jan; Louis, Renaud; Mahboub, Bassam; MƤkelƤ, Mika J.; Makris, Michael; Maurer, Marcus; MelĆ©n, Eric; Milenkovic, Branislava; Mohammad, Yousser; Moniuszko, Marcin; Montefort, Stephen; Bognanni, Antonio; Moreira, Andre; Moreno, Pablo; Mullol, Joaquim; Nadif, Rachel; Nakonechna, Alla; Navarro-Locsin, Cecilia Gretchen; Neffen, Hugo; Nekam, Kristof; Niedoszytko, Marek; Nunes, Elizabete; Brussino, Luisa; Nyembue Tshipukane, Dieudonne; OāHehir, Robyn; Ollert, Markus; Ohta, Ken; Okamoto, Yoshitaka; Okubo, Kimihiro; Olze, Heidi; Padukudru, Mahesh Anand; Palomares, Oscar; Pali-Schƶll, Isabella; Canonica, Giorgio Walter; Panzner, Petr; Palosuo, Kati; Park, Hae-Sim; Passalacqua, Giovanni; Patella, Vincenzo; Pawankar, Ruby; PĆ©trĆ©, BenoĆ®t; Pitsios, Constantinos; Plavec, Davor; Popov, Todor A.; Cherrez Ojeda, Ivan; Puggioni, Francesca; Quirce, Santiago; Raciborski, Filip; RamonaitĆ©, AgnĆ©; Recto, Marysia; Repka- Ramirez, MarĆa Susana; Roberts, Graham; Robles-Velasco, Karla; Roche, Nicolas; Rodriguez-Gonzalez, Monica; Cruz, Alvaro; Romualdez, Joel A.; Rottem, Menachem; Rouadi, Philip; Salapatas, Marianella; Sastre, Joaquin; Serpa, Faradiba; Sayah, Zineb; Scichilone, Nicola; Senna, Gianenrico; Sisul, Juan; Vecillas, Leticia De Las; SolĆ©, Dirceu; Soto-Martinez, Manuel E.; Sova, Milan; Sozinova, Olga; Stevanovic, Katarina; Suppli Ulrik, Charlotte; Szylling, Anna; Tan, Frances M.; Tantilipikorn, Pongsakorn; Bom, Ana Todo; Dykewicz, Mark; Tomic Spiric, Vesna; Tsaryk, Vladyslav; Tsiligianni, Ioanna; Urrutia-Pereira, Marilyn; Valentin Rostan, Marylin; Sofiev, Mikhail; Valovirta, Erkka; Van Eerd, Michiel; Van Ganse, Eric; Vasankari, Tuula; Gemicioglu, Bilun; Vichyanond, Pakit; Viegi, Giovanni; Wallace, Dana; Wang, De Yun; Waserman, Susan; Wong, Gary; Worm, Margitta; Yusuf, Osman; Zaitoun, Fares; Zidarn, Mihaela; Giovannini, Mattia; Haahtela, Tari; Jacobs, Marc; Jacomelli, Cristina; Klimek, Ludger; KvedarienÄ, Violeta; Linnemann, DĆ©sirĆ©e Larenas; Louis, Gilles; LourenƧo, Olga; Leemann, Lucas; Almeida, Mario Morais; Neves, Ana Luisa; Nadeau, Kari; Nowak, Artur; Palamarchuk, Yuliia; Palkonen, Susanna; Papadopoulos, Nikolaos G.; Parmelli, Elena; Pereira, Ana Margarida; Pfaar, Oliver; Regateiro, Frederico S.; SavourĆ©, Marine; Barata, LuĆs Taborda; Toppila-Salmi, Sanna Katriina; Torres, MarĆa Jose; Valiulis, Arunas; Ventura, Maria Teresa; Williams, SiĆ¢n; Yepes-NuƱez, Juan J.; Yorgancıoglu, Arzu; Zhang, Luo; Zuberbier, Jaron; Abdul Latiff, Amir; Abdullah, Baharudin; Agache, Ioana; Al-Ahmad, Mona; Al-Nesf, Maryam A Y; Al Shaikh, A.; Amaral, Rita; Ansotegui Zubeldia, Ignacio Javier; Asllani, Julijana; Balotro-Torres, Maria Cristina; Bergmann, Karl-Christian; Bernstein, Jonathan; Bindslev-Jensen, Carsten; Blaiss, Michael S.; Bonaglia, Cristina; Bonini, Matteo; BossĆ©, Isabelle; Braido, Fulvio; Caballero-Fonseca, Fernan; Camargos, Paulo; Martins, Pedro Carreiro; Casale, Thomas; Castillo-Vizuete, JosĆ©-Antonio; Cecchi, Lorenzo; Teixeira, Maria Do CĆ©u; Chang, Yoon-Seok; Loureiro, ClĆ”udia Chaves; Christoff, George; Ciprandi, Giorgio; Cirule, Ieva; Sousa, Jaime Correia De; Costa, ElĆsio; Cvetkovski, Biljana; De Vries, Govert; Del Giacco, Stefano; Devillier, Philippe; Dokic, Dejan; Douagui, Habib; Durham, Stephen; Enecilla, Maria Lourdes; Fiocchi, Alessandro; Fokkens, Wytske; Fontaine, Jean-FranƧois; Gawlik, Radoslaw; Gereda, Jose E.; Mata, Sara GilAbstract The traditional healthcare model is focused on diseases (medicine and natural science) and does not acknowledge patients' resources and abilities to be experts in their own lives based on their lived experiences. Improving healthcare safety, quality, and coordination, as well as quality of life, is an important aim in the care of patients with chronic conditions. Person-centered care needs to ensure that people's values and preferences guide clinical decisions. This paper reviews current knowledge to develop (1) digital care pathways for rhinitis and asthma multimorbidity and (2) digitally enabled, person-centered care.1 It combines all relevant research evidence, including the so-called real-world evidence, with the ultimate goal to develop digitally enabled, patient-centered care. The paper includes (1) Allergic Rhinitis and its Impact on Asthma (ARIA), a 2-decade journey, (2) Grading of Recommendations, Assessment, Development and Evaluation (GRADE), the evidence-based model of guidelines in airway diseases, (3) mHealth impact on airway diseases, (4) From guidelines to digital care pathways, (5) Embedding Planetary Health, (6) Novel classification of rhinitis and asthma, (7) Embedding real-life data with population-based studies, (8) The ARIA-EAACI (European Academy of Allergy and Clinical Immunology) strategy for the management of airway diseases using digital biomarkers, (9) Artificial intelligence, (10) The development of digitally enabled, ARIA person-centered care, and (11) The political agenda. The ultimate goal is to propose ARIA 2024 guidelines centered around the patient to make them more applicable and sustainable.
- Rhinitis associated with asthma is distinct from rhinitis alone: TARIAāMeDALL hypothesisPublication . Bousquet, Jean; MelĆ©n, Erik; Haahtela, Tari; Koppelman, Gerard; Togias, Alkis; Valenta, Rudolf; Akdis, Cezmi; Czarlewski, Wienczyslawa; Rothenberg, Marc; Valiulis, Arunas; Wickman, Magnus; Aberer, Werner; Heinrich, Joachim; Sisul, Juan; Nunes, Elizabete; Plavec, Davor; Agache, Ioana; Al-Ahmad, Mona; Serpa, Faradiba; Alobid, Isam; Kalayci, Omer; Vichyanond, Pakit; Giacco, S. Del; Fiocchi, Alessandro; Ansotegui Zubeldia, Ignacio Javier; Custovic, Adnan; Martins, Pedro Carreiro; Rouadi, Philip; Arshad, Syed Hasan; Asayag, Estrella; BĆ”rbara, Cristina; Abdullah, Baharudin; Moniuszko, Marcin; Tomazic, Peter Valentin; Popov, T. A.; Sayah, Zineb; Lkhagvaa, Battur; Nyembue Tshipukane , Dieudonne; Thomas, Mike; Bennoor, Kazi Saifuddin; Fyhrquist, Nanna Theresia; Irani, Carla; Berghea, Elena Camelia; ÄmužytÄ, Regina; De Blay, FrĆ©dĆ©ric; Toppila-Salmi, Sanna Katriina; Bergmann, Karl-Christian; Bernstein, D.; Bewick, M.; Casale, Thomas; Scheire, Sophie; Bumbacea, Roxana Silvia; Cepeda Sarabia, Alfonso; Puggioni, Francesca; Bush, Andrew; Chandrasekharan, Ramanathan; Ohta, Ken; Okubo, Kimihiro; Charpin, Denis; Gomez, R Maximiliano; Chen, Y. Z.; O'Hehir, Robyn; Cherrez Ojeda, Ivan; Bedbrook, Anna; To, Teresa; Chu, Derek K; Devillier, Philippe; Schmid-Grendelmeier, Peter; Didier, Alain; Repka-Ramirez, MarĆa Susana; Teixeira, Maria Do CĆ©u; Ispayeva, Zhanat; Dokic, Dejan; Quirce, Santiago; Douagui , Habib; Ivancevich, Juan Carlos; Viegi, Giovanni; Gotua, Maia; Todo-Bom, Ana; Blain, Hubert; Guzman, Maria Antonieta; Kalyoncu, Ali Fuat; Hagemann, Jan; Buhl, Roland; Hamamah, Samir; Caraballo, Luis; Jares, Edgardo; Wallace, Dana; Chivato, TomĆ”s; Jartti, Tuomas; Jassem, Ewa; Christoff, George; Julge, Kalev; Ogulur, Ismail; Kardas, Przemyslaw; Doulaptsi, Maria; Kirenga, Bruce; Helga, Kraxner; Durham, Stephen; Kull, Inger; Kulus, Marek; Daniel, Aguilar; Shamji, Mohamed; Kuna, Piotr; Nadif, Rachel; La Grutta, Stefania; Brightling, Chris; SamoliÅski, BolesÅaw; Lau, Susanne; Wang, De Yun; Cordeiro, Carlos Manuel Da Silva Robalo; SolĆ©, Dirceu; Le Thi Tuyet, Lan; Recto, Marysia; Ouedraogo, Solange; Halken, Susanne; Levin, Michael; Lipworth, Brian; LourenƧo, Olga; Mahboub, Bassam; Vandenplas, O.; Niedoszytko, Marek; Sastre, Joaquin; MartinezāInfante, E.; Kupczyk, Maciej; Torres, MarĆa Jose; Matricardi, Paolo Maria; Cecchi, Lorenzo; CeledĆ³n, Juan C; Miculinic, Neven; Roche, Nicolas; Just, Jocelyne; Migueres, Nicolas; Brussino, Luisa; Florin, Mihaltan; Olze, Heidi; SavourĆ©, Marine; Nekam, Kristof; Pali, Isabella; Okamoto, Yoshitaka; Palomares, O.; Lemonnier, NathanaĆ«l; Carlsen, Karin C. Lodrup; Palosuo, Kati; Soto-Martinez, Manuel; Panaitescu, Carmen; KvedarienÄ, Violeta; Panzner, P.; Braido, Fulvio; Tsiligianni, Ioanna; Rodriguez-Gonzalez, Monica; Scichilone, Nicola; Canonica, Giogio Walter; Passalacqua, Giovanni; Romantowski, Jan; Urrutia-Pereira, Marilyn; Filho, Nelson Augusto Rosario; Ollert, Markus W.; Rottem, Menachem; Chkhartishvili, Ekaterine; Sova, Milan; Valovirta, Erkka; Mohammad, Yousser; Sperl, Annette; Williams, SiĆ¢n; Spranger, Otto; Neffen, Hugo; Stelmach, Rafael; Burte, Emilie; Valentin Rostan, Marylin; Park, Hae-Sim; Van Ganse, Eric; Van Hage, Marianne; Pitsios, Constantinos; Vasankari, Tuula; Linnemann, DĆ©sirĆ©e Larenas; Loureiro, ClĆ”udia Chaves; Sagara, Hironori; Worm, Margitta; Yiallouros, Panayiotis; Yusuf, Osman; Zaitoun, Fares; Bonini, Matteo; HrubiÅ”ko, Martin; Cingi, C.; Dykewicz, Mark; Zernotti, Mario; Calderon, Moises; Halpin, David M.G.; Zidarn, Mihaela; Patella, Vincenzo; Sheikh, Aziz; Zuberbier, Jaron; Papadopoulos, Nikolaos; Louis, Renaud; Suppli Ulrik, Charlotte; Fonseca, JoĆ£o P.; Zuberbier, Torsten; Anto, Josep M.; Costa, Elisio; Eiwegger, Thomas; Bosnic-Anticevich, Sinthia; Cruz, Alvaro; Sousa, Jaime Correia de; Louis-Philippe, Boulet; Erhola, Marina; Cardona, Victoria; Carr, Warner; Gemicioglu, Bilun; Pawankar, Ruby; Fokkens, Wytske; Calvo, MĆ”rio; Garcia-Aymerich, J.; MƤkelƤ, Mika J.; Hofmann, Maja Ann; Klimek, Ludger; Makris, Michael; Mohamed Sayed, Zeinab; Maurer, Marcus; D'Amato, G.; Momas, Isabelle; Siroux, ValĆ©rie; Almeida, MĆ”rio Morais; Corrigan, Chris; Mullol, Joaquim; Montefort, Stephen; Jutel, Marek; Pham Thi, Nhan; Hossny, Elham; Akdis, Mubeccel; Pfaar, Oliver; Ventura, Maria Teresa; Regateiro, Frederico S.; Bindslev-Jensen, Carsten; Ring, Johannes; Bustamante, Mariona; Pinto, Bernardo Sousa; Kaidashev, Igor; Guerra, Stefano; Standl, Marie; Sunyer, J.; Keil, Thomas; Barata, LuĆs Taborda; Camargos, Paulo; Weiss, Scott; Naclerio, Robert; Yorgancıoglu, Arzu; Zhang, Luo; Nadeau, Kari; Abdul Latiff, AmirAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of āone-airway-one-disease,ā coined over 20āyears ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the āEpithelial Barrier Hypothesis.ā This review determined that the āone-airway-one-diseaseā concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme āallergicā (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.