Browsing by Issue Date, starting with "2018-11-18"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- Interferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell subset and plasmablastsPublication . Monteiro, Andreia; Cruto, Catarina; Rosado, Pedro; Rosado, Luiza; Fonseca, Ana Mafalda; Paiva, ArturOur aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27- and CD27+ memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27- and CD27+IgM+ memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment.