Percorrer por tipo de recurso "review article"
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- Automated and Intelligent Inspection of Airport Pavements: A Systematic Review of Methods, Accuracy and Validation ChallengesPublication . Feitosa, Ianca; Santos, Bertha; Almeida, Pedro G.; mdpiAirport pavement condition assessment plays a critical role in ensuring operational safety, surface functionality, and long-term infrastructure sustainability. Traditional visual inspection methods, although widely used, are increasingly challenged by limitations in accuracy, subjectivity, and scalability. In response, the field has seen a growing adoption of automated and intelligent inspection technologies, incorporating tools such as unmanned aerial vehicles (UAVs), Laser Crack Measurement Systems (LCMS), and machine learning algorithms. This systematic review aims to identify, categorize, and analyze the main technological approaches applied to functional pavement inspections, with a particular focus on surface distress detection. The study examines data collection techniques, processing methods, and validation procedures used in assessing both flexible and rigid airport pavements. Special emphasis is placed on the precision, applicability, and robustness of automated systems in comparison to traditional approaches. The reviewed literature reveals a consistent trend toward greater accuracy and efficiency in systems that integrate deep learning, photogrammetry, and predictive modeling. However, the absence of standardized validation protocols and statistically robust datasets continues to hinder comparability and broader implementation. By mapping existing technologies, identifying methodological gaps, and proposing strategic research directions, this review provides a comprehensive foundation for the development of scalable, data-driven airport pavement management systems.
- Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A reviewPublication . Pouso, Manuel António do Rosário ; Melo, Bruna Daniela Lopes ; Gonçalves, Joaquim; Louro, Ricardo; Mendonça, António; Correia, Ilídio Joaquim Sobreira ; de Melo-Diogo, DuarteMultiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into nanoparticles can overcome most of the solubility concerns. However, the ability of systemically administered drug-loaded nanomaterials to reach the tumor site has been vastly overestimated, limiting their clinical translation. The drugs’ and drug-loaded nanomaterials’ systemic administration issues have propelled the development of hydrogels capable of performing their direct/local delivery into the tumor site. The use of these macroscale systems to mediate a tumor-confined delivery of the drugs/drugs-loaded nanomaterials grants an improved therapeutic efficacy and, simultaneously, a reduction of the side effects. The manufacture of these hydrogels requires the careful selection and tailoring of specific polymers/materials as well as the choice of appropriate physical and/or chemical crosslinking interactions. Depending on their administration route and assembling process, these matrices can be classified as injectable in situ forming hydrogels, injectable shear-thinning/selfhealing hydrogels, and implantable hydrogels, each type bringing a plethora of advantages for the intended biomedical application. This review provides the reader with an insight into the application of injectable and implantable hydrogels for performing the tumor-confined delivery of drugs and drug-loaded nanomaterials.
- KUHN, T. The Last Writings of Thomas S. Kuhn: Incommensurability in Science. Chicago: University of Chicago Press, 2022Publication . Castro, EduardoOs escritos reunidos neste livro dividem-se em duas partes. A primeira parte é composta por dois textos ministrados no âmbito de conferências. A segunda parte é o livro inacabado de Thomas Kuhn, A Pluralidade dos Mundos: uma Teoria Evolucionista do Desenvolvimento Científico. [...]