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- Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cellsPublication . Gomes, Inês; Santos, Cecilia; Socorro, Sílvia; Baptista, CláudioSTEAP1 is over-expressed in several types of tumors, especially prostate cancer, where it is localized in the plasma membrane of epithelial cells, at cell-cell junctions. Its role in prostate carcinogenesis and its regulation in prostate cells remain unknown. Therefore, we propose to study the effect of sex hormones in the regulation of STEAP1 expression in prostate cells in vitro and in vivo.