Loading...
2 results
Search Results
Now showing 1 - 2 of 2
- Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular CarcinomaPublication . Mamede, Ana Catarina Manjolinha; Guerra, S; Laranjo, Marta; Santos, K; Carvalho, Maria J; Carvalheiro, Tiago; Moura, P; Paiva, A; Abrantes, Ana M; Baptista, Cláudio; Botelho, M FThe anticancer effects of human amniotic membrane (hAM) have been studied over the last decade. However, the action mechanisms responsible for these effects are not fully understood until now. Previously results reported by our team proved that hAM is able to induce cytotoxicity and cell death in hepatocellular carcinoma (HCC), a worldwide high incident and mortal cancer. Therefore, this experimental study aimed to investigate the cellular targets of hAM protein extracts (hAMPE) in HCC through in vitro studies. Our results showed that hAMPE is able to modify oxidative stress environment in all HCC cell lines, as well as its cell cycle. hAMPE differently targets deoxyribonucleic acid (DNA), P21, P53, β-catenin and multidrug resistance (MDR) proteins in HCC cell lines. In conclusion, hAMPE has several targets in HCC, being clear that the success of this treatment depends of a personalized therapy based on the biological and genetic characteristics of the tumor.
- Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failurePublication . Martins, Sílvia; Carvalheiro, Tiago; Laranjeira, Paula; Martinho, António; Elvas, Luís; Gonçalves, Lino; Tomaz, C. T.; António, Natália; Paiva, ArturIL-17-producing T cells have been implicated in the inflammatory milieu of chronic heart failure (CHF), which implies a dismal prognosis in affected patients. The aim of this study was to evaluate the impact of cardiac resynchronization therapy (CRT) on the frequency and functional activity of Th17 and Tc17 cells, as well as, on IL-17 mRNA expression in patients with CHF.