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- Hyaluronic acid - Based wound dressings: A reviewPublication . Graça, Mariana F. P.; Miguel, Sónia P.; Cabral, Cátia S. D.; Correia, I.J.Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a major component of skin extracellular matrix (ECM) and it is involved in the inflammatory response, angiogenesis, and tissue regeneration process. Due to the intrinsic properties of HA (such as biocompatibility, biodegradability and hydrophilic character), it has been used to produce different wound dressings, namely sponges, films, hydrogels, and electrospun membranes. Herein, an overview of the different HA-based wound dressings that have been produced so far is provided as well as the future directions regarding the strategies aimed to improve the mechanical stability of HA-based wound dressings, along with the incorporation of biomolecules intended to ameliorate their biological performance during the healing process.
- Chitin- and chitosan-based strategies in wound healingPublication . Cabral, Cátia S. D.; Graça, Mariana F. P.; Moreira, André F.; Diogo, Duarte de Melo; Correia, I.J.Nowadays, chronic wounds are still a huge health problem with a high impact on the patients’ quality of life. In this way, the development of an ideal wound dressing is of utmost importance. To accomplish that, researchers have been using natural polymers to produce new types of dressings, that can activate/direct specific cellular responses, leading to an improved healing process. Among the natural polymers, chitin presents notable antibacterial and antiinflammatory properties that are crucial for enhancing the wound healing process. Moreover, chitosan, a deacetylated form of chitin, has been one of the most used biopolymers due to its straightforward processability into different forms, antimicrobial activity, and capacity to promote/accelerate the healing process. This chapter provides an overview of the properties exhibited by chitin and chitosan as well as examples of their application in the development of dressings aimed to improve the healing process.