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- Effects of Low-Volume Resistance Training in Individuals with Cognitive Impairment: The impact on Muscle, Metabolic, Inflammatory, Oxidative Stress, and Cognitive MarkersPublication . Ferreira, Mariana Sofia Lopes; Fonseca, Carla Sofia Pais; Marques, Mário António CardosoAging is associated with physiological, inflammatory, and cognitive changes that increase the risk of neurodegenerative diseases and compromise quality of life. Despite the known benefits of physical exercise, adherence to exercise programs among older adults remains limited, posing a challenge for health promotion in this population. This study aimed to investigate the effects of an 8-week low-volume resistance training program on aging-related markers in a predominantly older population with cognitive impairment. Twenty-eight participants (86 ± 10 years) took part in the study, which was part of the Trainb4Brain program, based on single-set of low-volume resistance training. The choice of a single-set protocol was based on the premise that even low volumes of exercise can provide meaningful benefits while supporting long-term engagement in older adults. Physiological and biochemical parameters, including lipid profile, inflammatory markers, oxidative stress indicators, a cognitive marker and muscle-related measures, were assessed before and after the intervention. The results showed improvements in some lipid parameters and changes at the muscular level without indications of tissue damage, suggesting that short-duration resistance training can induce beneficial adaptations while remaining safe for this population. These findings support the feasibility of low-volume resistance training as a strategy to promote health in older adults. They also show that training programs can be adapted to individual needs, optimizing benefits while maintaining adherence and safety. Given these promising results, further research is warranted to better understand the long-term effects and potential mechanisms of the resistance training in older populations.