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- EUFOREA/EPOS2020 statement on the clinical considerations for CRSwNP carePublication . Hellings, Peter; Alobid, Isam; Anselmo‐Lima, Wilma T.; Bernal‐Sprekelsen, Manuel; Bjermer, Leif; Caulley, Lisa; Chaker, Adam; Constantinidis, Jannis; Conti, Lucio; De Corso, Eugenio; Desrosiers, Martin; Diamant, Zuzana; Gevaert, Philippe; Han, Jie; Heffler, Enrico; Hopkins, Claire; Landis, Basile; Lourenço, Olga; Lund, Valerie; Luong, Amber U.; Mullol, Joaquim; Peters, Anju; Philpott, Carl; Reitsma, Sietze; Ryan, Dermot; Scadding, Glenis; Senior, Brent; Tomazic, Peter Valentin; Toskala, Elina; Van Zele, Thibaut; Viskens, An‐Sofie; Wagenmann, Martin; Fokkens, WytskeFollowing the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recommended to receive oral corticosteroids, (revision) sinus surgery, systemic biologicals and/or aspirin treatment after desensitization (ATAD). Given the major differences in indications, outcomes, practical considerations, risks and costs of these key pillars of treatment, there is a growing need to define criteria for each treatment option and list the clinically relevant and major considerations for them. This EUFOREA document therefore provides an expert panel overview of the expected outcomes, specific considerations and (contra)indications of the five major treatment arms of severe uncontrolled CRSwNP: oral corticosteroids, primary and revision sinus surgery, biological treatment and ATAD. This overview of treatment considerations is needed to allow physicians and patients to consider the different options in the context of providing optimal and personalized care for severe uncontrolled CRSwNP. In conclusion, the five major treatment options for severe uncontrolled CRSwNP have intrinsic advantages, specific indications and considerations that are of importance to the patient, the physician and the society. This EUFOREA statement supports the unmet need to define criteria for the indication of every treatment pillar of CRSwNP.
- Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseasesPublication . Bousquet, Jean; Schünemann, Holger; Togias, Alkis; Erhola, Marina; Hellings, Peter; Zuberbier, Torsten; Agache, Ioana; Ansotegui Zubeldia, Ignacio Javier; Anto, Josep M.; Bachert, Claus; Becker, Sven; Kvedarienė, Violeta; Yusuf, Osman; Ohta, Ken; Moda, Giuliana; Münter, Lars; Chu, Derek K; Lourenço, Olga; Ryan, Dermot; Kuna, Piotr; Devillier, Philippe; Novellino, Enrico; Bergmann, Karl-Christian; Bonini, Mateo; Billo, Nils; Mathieu-Dupas, Eve; Portejoie, Fabienne; Reitsma, Sietze; Farrell, John; Sheikh, Aziz; Haahtela, Tari; Dykewickz, Marc; Morais-Almeida, Mario; Namazova-Baranova, Leyla; Cvetkosvki, Biljana; Fiocchi, Alessandro; Stelmach, Rafael; Samoliński, Bolesław; Brightling, Christofer E; Cardona, Victoria; Buhl, Roland; Miculinic, Neven; Salimäki, Johanna; Ebisawa, Motohiro; Iaccarino, Guido; Bedolla-Barajas, Martin; Roche, Nicolas; Guldemond, Nick A; Dauvilliers, Yves; Palkonen, Susanna; Fonseca, Joao A; Basagaña, Xavier; Cartier, Christine; Chkhartishvili, Ekaterine; Cecchi, Lorenzo; Monti, Ricardo; Suppli Ulrik, Charlotte; Kleine-Tebbe, Jorg; Annesi-Maesano, Isabella; Kardas, Przemyslaw; Garcia-Aymerich, Judith; Pugin, Benoit; Picard, Robert; Fontaine, Jean F; Colgan, Elaine; Custovic, Adnan; Murray, Ruth; van der Kleij, Rianne; Bjermer, Leif; Lodrup Carlsen, Karin C; Jutel, Marek; Solé, Dirceu; Williams, Sian; Illario, Maddalena; Ouedraogo, Solange; Nekam, Kristof; Wang, De Y; Buonaiuto, Roland; Lieberman, Philip; Todo-Bom, Ana; Bindslev-Jensen, Carsten; Kritikos, Vicky; Price, David; Paulino, Ema; Cepeda Sarabia, Alfonso M; De Manuel Keenoy, Esteban; Viart, Frédéric; Okubo, Kimihiro; Sanchez-Borges, Mario; Dubakiene, Ruta; Courbis, Anne Lise; Bourrez, Jean Marc; Gaga, Mina; Thibaudon, Michel; Guzman, Maria Antonieta; Dantas, Carina; Menditto, Enrica; Pinnock, Hilary; Keil, Thomas; De Feo, Giulia; Gotua, Maia; Silva, J da; Laune, Daniel; Williams, Dennis M; Zeng, Stéphane; Montefort, Steve; Hajjam, Jawad; Bedbrook, Anna; González Diaz, Sandra; Neou, Angelo; Marien, Gert; Marshall, Gailen D; Malva, Joao; Vandenplas, Olivier; Valiulis, Arunas; Akdis, Cezmi A; Pali-Schöll, Isabella; Kalayci, Omer; Gamkrelidze, Amiran; Nyembue Tshipukane , Dieudonne; Zidarn, Mihaela; Muraro, Antonella; Costa, Elísio; Bonniaud, Philippe; Kaidashev, Igor; Matricardi, Poalo M; Menditto, Enrica; Melo-Gomes, Elisabete; Waserman, Susan; Bennoor, Kazi Saifuddin; Prokopakis, Emmanuel P; Di Capua, Stefania; Jung, Ki-Suck; Plavec, Davor; Neffen, Hugo; Papadopoulos, Nikos; Gemicioglu, Bilun; Lipworth, Brian; Mihaltan, Florin; Mohammad, Yousser; Yorgancıoglu, Arzu; Bouchard, Jacques; Sisul, Juan-Carlos; Leonardini, Lisa; Rottem, Menahenm; Pfaar, Oliver; Ventura, Maria Teresa; Ivancevich, Juan C; Panzner, Peter; Brusselle, Guy; Zhang, Luo; Carriazo, Ana M; Manning, Patrick; Stellato, Cristina; Romano, Antonino; Bialek, Slawomir; Kull, Inger; Raciborski, Filip; Mullol, Joaquin; Klimek, Ludger; Meltzer, Eli O; Spranger, Otto; Brozek, Jan; Boulet, Louis P; Somekh, David; Valovirta, Erkka; Rolland, Christine; Mogica Martinez, Maria Dolores; Valenta, Rudolf; Casale, Thomas; Benveniste, Samuel; O'Hehir, Robyn; Mösges, Ralf; Eller, Esben; Schmid-Grendelmeir, Peter; Briedis, Vitalis; Popov, Ted A; Napoli, Luigi; O'B Hourihane, John; Joos, Guy; Chavannes, Niels; Picard, Robert; Naclerio, Robert; Bewick, Michael; Sousa, Jaime Correia de; Dokic, Dejan; Yiallouros, Panayiotis; Cruz, Alvaro; Loureiro, Claudia C; Phillips, Jim; To, Teresa; Valentin Rostan, Marylin; Tomazic, Peter Valentin; Carr, Warner; Khaitov, Mussa; Bosse, Isabelle; Okamoto, Yoshitaka; Czarlewski, Wienczyslawa; Pereira, Ana-Maria; Le Thi Tuyet, Lan; Zernotti, Mario; Fink-Wagner, Antjie; Masjedi, Mohamed R; Rosario, Nelson; Vezzani, Giorgio; Wagenmann, Martin; Viegi, Giovanni; Cingi, Cemal; Louis, Renaud; Vasankari, Tuula; Rodo, Xavier; Toppila-Salmi, Sanna; Illario, Maddalena; Ierodiakonou, Despo; Park, Hae-Sim; Fokkens, Wytske J; Wickman, Magnus; Wroczynski, Piotr; D'Amato, Gennaro; Maspero, Jorge F; Sova, Milan; Bateman, Eric; Roller-Wirnsberger, Regina E; Kowalski, Marek L; Rajabian-Söderlund, Rojin; Pham-Thi, Nhân; Emuzyte, Regina; Dedeu, Antoni; Mercier, Jacques; Valero, Antonio; Arnavielhe, Sylvie; Mahboub, Bassam; Sooronbaev, Talant; Walker, Samantha; Humbert, Marc; Gomez, Maximiliano; Wallace, Dana; Blain, Hubert; Melén, Erik; El-Gamal, Yaya; Khaltaev, Nikolai; Bosnic-Anticevich, Sinthia; Wong, Gary; Canonica, Giorgo W; Milenkovic, Branislava; Mair, Alpana; Linnemann, Désirée Larenas; Zar, Heather J; Onorato, Gabrielle; Pépin, Jean-Louis; Tsiligianni, Ioanna; Zhong, Nan SBackground: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Nextgeneration guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.