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Advisor(s)
Abstract(s)
As plantas medicinais são o recurso de saúde mais acessível e disponível para grande parte das comunidades no mundo, principalmente em África onde a rede de saúde é bastante deficiente. A presente investigação centra-se na identificação de compostos químicos da planta Phyllanthus welwitschianus. As folhas da planta com que se fez o estudo, foram recolhidas na localidade da Umpata, província da Huila em Angola, onde a população utilizam-nas para tratamento de feridas.
O material vegetal foi macerado e exaustivamente extraído à temperatura ambiente com metanol, posteriormente procedeu-se ao fracionamento de uma amostra do extrato de metanol. Essa amostra foi fracionada com mistura de vários solventes de polaridades crescentes, resultando em dez frações, das quais, em três delas isolaram-se três compostos: tetracos-1-eno, ß-sitosterol e sacarose.
O tetracos-1-eno foi isolado a partir da fração hexano/acetato de etilo 9:1, o ß-sitosterol foi isolado a partir da fração hexano/acetato de etilo 1:1, e a sacarose isolada a partir da fração de acetato etilo/metanol 1:1, os compostos foram caracterizados por métodos espectroscópicos de IV, RMN 1D e 2D. Estes resultados foram comparados com os referenciados na bibliografia, confirmando que os compostos ß-sitosterol e sacarose, já tinham sido identificados no mesmo género.
Medicinal plants are the most accessible and available health resource for most communities in the world, especially in Africa where the health care network is quite deficient. The present research focuses on the identification of chemical compounds of the plant Phyllanthus welwitschianus. The leaves of the study plant were collected in Umpata, Huila province in Angola, where the population used them to treat wounds. The plant material was macerated and exhaustively extracted with methanol at room temperature. A sample of the methanol extract was f fractionated with a mixture of several solvents of increasing polarities, resulting in ten fractions, of which three compounds were isolated: tetracos-1-ene, ß-sitosterol, and sucrose. Tetracos-1-ene was isolated from the 9:1 hexane/ethyl acetate fraction, ß-sitosterol was isolated from the 1:1 hexane/ethyl acetate fraction, and sucrose was isolated from the 1:1 ethyl acetate/methanol fraction, the compounds were characterized by spectroscopic methods namely IR, 1D and 2D NMR. These results were compared with those referenced in the literature, confirming that ß-sitosterol and sucrose had already been identified in the same genera.
Medicinal plants are the most accessible and available health resource for most communities in the world, especially in Africa where the health care network is quite deficient. The present research focuses on the identification of chemical compounds of the plant Phyllanthus welwitschianus. The leaves of the study plant were collected in Umpata, Huila province in Angola, where the population used them to treat wounds. The plant material was macerated and exhaustively extracted with methanol at room temperature. A sample of the methanol extract was f fractionated with a mixture of several solvents of increasing polarities, resulting in ten fractions, of which three compounds were isolated: tetracos-1-ene, ß-sitosterol, and sucrose. Tetracos-1-ene was isolated from the 9:1 hexane/ethyl acetate fraction, ß-sitosterol was isolated from the 1:1 hexane/ethyl acetate fraction, and sucrose was isolated from the 1:1 ethyl acetate/methanol fraction, the compounds were characterized by spectroscopic methods namely IR, 1D and 2D NMR. These results were compared with those referenced in the literature, confirming that ß-sitosterol and sucrose had already been identified in the same genera.
Description
Keywords
Avaliação Química Phyllanthus Welwitschianus Plantas Medicinais