Repository logo
 
Publication

Combining Photothermal‐Photodynamic Therapy Mediated by Nanomaterials with Immune Checkpoint Blockade for Metastatic Cancer Treatment and Creation of Immune Memory

2021-05-06Journal article Open access
Simple item page
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorAlves, Cátia
dc.contributor.authorMoreira, André
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, I.J.
dc.contributor.authorDiogo, Duarte de Melo
dc.date.accessioned2021-07-30T10:40:42Z
dc.date.available2023-07-30T00:30:21Z
dc.date.issued2021-05-06
dc.description.abstractThe pursuit of effective treatments for metastatic cancer is still one of the most intensive areas of research in the biomedical field. In a not-so-distant past, the scientific community has witnessed the rise of immunotherapy based on immune checkpoint inhibitors (ICIs). This therapeutic modality intends to abolish immunosuppressive interactions, re-establishing T cell responses against metastasized cancer cells. Despite the initial enthusiasm, the ICIs were later found to be associated with low clinical therapeutic outcomes and immune-related side effects. To address these limitations, researchers are exploring the combination of ICIs with nanomaterial-mediated phototherapies. These nanomaterials can accumulate within the tumor and produce, upon interaction with light, a temperature increase (photothermal therapy) and/or reactive oxygen species (photodynamic therapy), causing damage to cancer cells. Importantly, these photothermal-photodynamic effects can pave the way for an enhanced ICI-based immunotherapy by inducing the release of tumor-associated antigens and danger-associated molecular patterns, as well as by relieving tumor hypoxia and triggering a pro-inflammatory response. This progress report analyses the potential of nanomaterial-mediated photothermal-photodynamic therapy in combination with ICIs, focusing on their ability to modulate T cell populations leading to an anti-metastatic abscopal effect and on their capacity to generate immune memory that prevents tumor recurrence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/adfm.202010777pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11199
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationHealth Sciences Research Centre
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.subjectCancerpt_PT
dc.subjectImmunotherapypt_PT
dc.subjectNanomedicinept_PT
dc.subjectNear infraredpt_PT
dc.subjectPhotodynamicpt_PT
dc.subjectPhototherapypt_PT
dc.subjectPhotothermalpt_PT
dc.titleCombining Photothermal‐Photodynamic Therapy Mediated by Nanomaterials with Immune Checkpoint Blockade for Metastatic Cancer Treatment and Creation of Immune Memorypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.citation.issue29pt_PT
oaire.citation.startPage2010777pt_PT
oaire.citation.titleAdvanced Functional Materialspt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameSousa
person.familyNameLopes Melo
person.familyNameAlves
person.familyNameMoreira
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameAna Rita Lima
person.givenNameBruna Daniela
person.givenNameCátia Gomes
person.givenNameAndré Ferreira
person.givenNameAntónio
person.givenNameIlídio
person.givenNameDuarte
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifierC2z5x04AAAAJ
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id5717-CB52-B4E5
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright do artigo foi cedido à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione8d3f1a4-dad6-4ea4-a299-7ed0ae317f6a
relation.isAuthorOfPublicationd375e555-1edb-4f4e-b888-9973932767ff
relation.isAuthorOfPublication2fe5ed93-8d1b-4f2b-9071-7566c0db9c0b
relation.isAuthorOfPublicatione20bf724-86f1-4fc8-800d-39ff19b624b1
relation.isAuthorOfPublicationfbccceb8-2850-4fe1-ae4f-4aeded7bf32a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication8525f1be-ff8f-4e46-b158-e59928e8a3e5
relation.isAuthorOfPublication.latestForDiscovery8525f1be-ff8f-4e46-b158-e59928e8a3e5
relation.isProjectOfPublicationc7cee677-067c-47b2-ab19-b2dd5b0fda9d
relation.isProjectOfPublication4d63028b-d069-45f9-a7a2-ace9670c95e7
relation.isProjectOfPublication03cd9d9a-04c7-41da-88e0-3bdff82c2db7
relation.isProjectOfPublication.latestForDiscoveryc7cee677-067c-47b2-ab19-b2dd5b0fda9d

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2021 Lima-Sousa AFM.pdf
Size:
2.25 MB
Format:
Adobe Portable Document Format
Download

Collections

FCS - DCM | Documentos por Auto-Depósito
FC - DQ | Documentos por Auto-Depósito
ICI - CICS | Documentos por Auto-Depósito