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Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissues

2008-07Journal article Restricted access
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dc.contributor.authorMaia, C J
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorSantos, Cecília
dc.date.accessioned2019-10-08T13:13:43Z
dc.date.available2019-10-08T13:13:43Z
dc.date.issued2008-07
dc.description.abstractOAS1 belongs to a protein family of interferon-induced enzymes characterized by their ability to catalyze the synthesis of 2'-5'-linked oligomers of adenosine from ATP (2-5A). 2-5A bind to the latent Ribonuclease L (RNase L), which subsequently dimerizes into the active form, acquiring the capacity of cleaving cellular and viral mRNA. Several studies indicate that OAS1 is an important inducer of apoptosis in human cancer cells and that it may be regulated by 17beta-estradiol (E(2)). The aim of this study was to characterize OAS1 gene expression in rat mammary gland and prostate, and to analyze its regulation by E(2) in both tissues. It is demonstrated that OAS1g is the most abundant OAS1 gene expressed in both tissues, and that OAS1 protein is present in the nucleus of rat mammary gland and prostate epithelial cells. In addition, it is shown by Real Time PCR that OAS1g is up-regulated by E(2) in rat mammary gland, but down-regulated in prostate, suggesting that the OAS1g gene may be related to estrogen dependent pathways in rat mammary gland and prostate physiology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11010-008-9771-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7220
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectOAS1pt_PT
dc.subjectEstrogenpt_PT
dc.subjectMammary glandpt_PT
dc.subjectProstatept_PT
dc.titleCharacterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissuespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage121pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage113-21pt_PT
oaire.citation.volume314pt_PT
person.familyNameMaia Baptista
person.familyNameSocorro
person.familyNameSchmitt
person.familyNameSANTOS
person.givenNameCláudio Jorge
person.givenNameSílvia Cristina da Cruz Marques
person.givenNameFernando
person.givenNameCecília Reis Alves
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.ciencia-id761A-7ED2-D68F
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-8181-488X
person.identifier.orcid0000-0003-1006-6946
person.identifier.orcid0000-0001-6074-7825
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id23097994600
person.identifier.scopus-author-id7202545664
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1080c532-c737-4b60-bc44-1d18e3c877d7
relation.isAuthorOfPublication1fb06949-0e6c-41a6-bb25-11885e7f0e9a
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relation.isAuthorOfPublication.latestForDiscovery1080c532-c737-4b60-bc44-1d18e3c877d7

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