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Amniotic membrane: from structure and functions to clinical applications

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dc.contributor.authorMamede, Ana Catarina Manjolinha
dc.contributor.authorCarvalho, Maria J
dc.contributor.authorAbrantes, Ana M
dc.contributor.authorLaranjo, Marta
dc.contributor.authorMaia, C J
dc.contributor.authorBotelho, M F
dc.date.accessioned2019-11-27T16:51:22Z
dc.date.available2019-11-27T16:51:22Z
dc.date.issued2012
dc.description.abstractAmniotic membrane (AM) or amnion is a thin membrane on the inner side of the fetal placenta; it completely surrounds the embryo and delimits the amniotic cavity, which is filled by amniotic liquid. In recent years, the structure and function of the amnion have been investigated, particularly the pluripotent properties of AM cells, which are an attractive source for tissue transplantation. AM has anti-inflammatory, anti-bacterial, anti-viral and immunological characteristics, as well as anti-angiogenic and pro-apoptotic features. AM is a promoter of epithelialization and is a non-tumorigenic tissue and its use has no ethical problems. Because of its attractive properties, AM has been applied in several surgical procedures related to ocular surface reconstruction and the genito-urinary tract, skin, head and neck, among others. So far, the best known and most auspicious applications of AM are ocular surface reconstruction, skin applications and tissue engineering. However, AM can also be applied in oncology. In this area, AM can prevent the delivery of nutrients and oxygen to cancer cells and consequently interfere with tumour angiogenesis, growth and metastasis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMamede AC; Carvalho MJ; Abrantes AM; Laranjo M; Maia CJ; Botelho MF. 2012. "Amniotic membrane: from structure and functions to clinical applications". Cell and Tissue Research 349 (2): 447-458.pt_PT
dc.identifier.doi10.1007/s00441-012-1424-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7632
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAmniotic membranept_PT
dc.subjectOcular surface reconstructionpt_PT
dc.subjectSkinpt_PT
dc.subjectTissue engineeringpt_PT
dc.subjectOncologypt_PT
dc.titleAmniotic membrane: from structure and functions to clinical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage458pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage447pt_PT
oaire.citation.titleCell and Tissue Researchpt_PT
oaire.citation.volume349pt_PT
person.familyNameCarvalho
person.familyNameAbrantes
person.familyNameLaranjo
person.familyNameMaia Baptista
person.familyNameBotelho
person.givenNameMaria J
person.givenNameAna M
person.givenNameMarta
person.givenNameCláudio Jorge
person.givenNameMaria Filomena
person.identifier2085222
person.identifierR-000-10V
person.identifierI-6040-2012
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
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person.identifier.orcid0000-0002-5658-5445
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person.identifier.ridG-6913-2018
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person.identifier.scopus-author-id55440132400
person.identifier.scopus-author-id26029747600
person.identifier.scopus-author-id7801545833
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7005751167
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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