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Publication
Efeito da Privação de Sono na Resistência à Insulina
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| Documento em Acesso Embargado até dia 02-12-2026. Tente solicitar cópia ao autor carregando no ficheiro | 714.17 KB | Adobe PDF |
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Abstract(s)
Grande parte da vida de um ser humano é passada a dormir, e como é sabido, sono adequado tem um papel fundamental para o bem-estar geral e funções cognitivas e fisiológicas. No entanto, numa sociedade cada vez mais focada em produtividade, a problemática da falta de sono torna-se cada vez mais preponderante. Assim, sendo esse um hábito muito adotado por parte da população é importante questionarmo-nos quanto aos seus possíveis impactos. Por outro lado, também se tem observado um aumento da incidência de Diabetes Mellitus, uma patologia crónica que representa elevados custos para os sistemas de saúde, e que está associada a aumento da resistência à insulina. Torna-se por isso pertinente tomar decisões diárias no sentido de contrariar esta tendência e viver anos de vida com mais qualidade, tornando este tema importante no contexto atual. Nesse sentido, com este trabalho pretendo analisar a literatura existente acerca da possível relação existente entre a privação de sono e as suas consequências metabólicas, nomeadamente ao nível do desenvolvimento de resistência à insulina. Para tal, irei realizar uma revisão da literatura nos últimos 10 anos com recurso às bases de dados Pubmed, Scopus e Web of Science com as seguintes associações de palavraschave “sleep deprivation” e “insulin resistance”. Nos estudos analisados registou-se uma diminuição da sensibilidade à insulina em situação de privação de sono, mesmo na presença de variações entre protocolos. Foi possível também verificar a associação entre a privação de sono e o aumento de ácidos gordos não esterificados (AGNE). No entanto, isto não aconteceu para outros parâmetros como cortisol, metanefrinas e normetanefrinas, onde os resultados não foram consensuais entre estudos. Assim, apesar de a hipótese colocada inicialmente se confirmar, isto é que a privação de sono promove a resistência à insulina, os mecanismos através dos quais tal acontece estão ainda pouco esclarecidos. Neste sentido, e tendo em conta as dificuldades que o seu estudo muitas vezes impõe, é importante a realização de mais pesquisa que seja o mais rigorosa possível.
Every human being spends a considerable amount of time sleeping, and as we know, adequate sleep has a fundamental role in well-being as well as cognitive and physiological functions. However, we live in a society that has become progressively more focused on productivity, and as a result, the problem of sleep deprivation has become even more relevant. Therefore, being that this a habit adopted by a significant amount of people, we must ask ourselves about its possible impacts. On the other hand, it has also been reported an increase in Diabetes Mellitus cases, a chronic pathology that imposes a big burden on health systems, and that is associated with the rise in insulin resistance. So, it is highly important to make daily decisions to counteract this tendency and live with a better quality of life, which makes this theme an important one in our current context. In this sense, with my research, I entend to analyse the existing literature regarding the possible relation between sleep deprivation and its metabolic consequences, specifically the development of insulin resistance. Accordingly, I will review the literature produced in the last 10 years using the databases Pubmed, Scopus, and Web of Science with the following associations of keywords “sleep deprivation” and “insulin resistance.” Studies showed that in situations of sleep deprivation, there was a decrease in insulin sensitivity, even when there was variation between protocols. Also, it was noticeable an association between sleep deprivation and an increase in non-esterified fatty acids. However, this didn’t happen regarding other parameters such as cortisol, metanephrines, and normetanephrines, where the results weren’t consistent among studies. Thus, even though the initial hypothesis has been confirmed, namely that sleep deprivation promotes insulin resistance, the mechanisms through which it happens have not yet been well clarified. In this sense, and being aware of the difficulties that its study imposes, it’s important to research this topic further in the most rigorous way possible.
Every human being spends a considerable amount of time sleeping, and as we know, adequate sleep has a fundamental role in well-being as well as cognitive and physiological functions. However, we live in a society that has become progressively more focused on productivity, and as a result, the problem of sleep deprivation has become even more relevant. Therefore, being that this a habit adopted by a significant amount of people, we must ask ourselves about its possible impacts. On the other hand, it has also been reported an increase in Diabetes Mellitus cases, a chronic pathology that imposes a big burden on health systems, and that is associated with the rise in insulin resistance. So, it is highly important to make daily decisions to counteract this tendency and live with a better quality of life, which makes this theme an important one in our current context. In this sense, with my research, I entend to analyse the existing literature regarding the possible relation between sleep deprivation and its metabolic consequences, specifically the development of insulin resistance. Accordingly, I will review the literature produced in the last 10 years using the databases Pubmed, Scopus, and Web of Science with the following associations of keywords “sleep deprivation” and “insulin resistance.” Studies showed that in situations of sleep deprivation, there was a decrease in insulin sensitivity, even when there was variation between protocols. Also, it was noticeable an association between sleep deprivation and an increase in non-esterified fatty acids. However, this didn’t happen regarding other parameters such as cortisol, metanephrines, and normetanephrines, where the results weren’t consistent among studies. Thus, even though the initial hypothesis has been confirmed, namely that sleep deprivation promotes insulin resistance, the mechanisms through which it happens have not yet been well clarified. In this sense, and being aware of the difficulties that its study imposes, it’s important to research this topic further in the most rigorous way possible.
Description
Keywords
Privação de Sono Resistência à Insulina Diabetes Mellitus Homeostase da Glicose Sleep Deprivation Insulin Resistance Glucose Homeostasis