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Abstract(s)
A anemia ferropénica afeta milhares de pessoas globalmente sendo as mulheres as mais
afetadas. Esta anemia caracteriza-se pela deficiência de ferro no organismo que pode
ocorrer por vários motivos, pela diminuição do consumo de ferro na dieta, aumento do
consumo deste pelo metabolismo, elevada perda sanguínea ou ainda em casos de
inflamação crónica. O diagnóstico de anemia ferropénica ou a identificação de
deficiência férrica antes mesmo de uma anemia é um processo desafiante, pois é
necessário avaliar vários parâmetros bioquímicos simultaneamente para um
diagnóstico correto devido à complexidade do metabolismo do ferro, sendo que muitos
destes parâmetros são afetados por motivos externos à patologia. A identificação de
fatores precoces de ferropénia é de extrema relevância de forma a prevenir a anemia
ferropénica. Neste sentido, o objetivo deste trabalho foi verificar se os novos
parâmetros fornecidos pelo equipamento hematológico Beckman Coulter DxH800,
mais concretamente o low haemoglobin density e microcytic anemia factor poderão
ser utilizados como parâmetros precoces de uma anemia por deficiência de ferro. De
forma retrospetiva foram estudadas 367 amostras entre 2018 e 2019 provenientes do
serviço de Imunohemoterapia. No total temos 190 (51,8%) amostras do sexo feminino e
177 (48,2%) do sexo masculino. A maioria dos pacientes encontra-se na faixa etária dos
35 aos 65 anos, sendo os idosos (> 65 anos) a segunda faixa etária mais prevalente. Os
jovens adultos representam apenas 11,7% da população em estudo. As populações
foram separadas em população com anemia e população sem anemia em ambos os
sexos através do parâmetro hemoglobina (<12 g/dL para mulheres e <13 g/dL) para
homens). Numa segunda fase, ambos os sexos foram separados em função da ferritina
(<100 ng/mL) de forma a definir 2 grupos distintos: com ferropénia e sem ferropénia.
Cerca de 30% das mulheres e 26,6% dos homens apresentam anemia, e 93,7% das
mulheres e 41,2% dos homens apresentam ferropénia. O LHD em pessoas com anemia
apresenta valores mais elevados do que em pessoas sem anemia, no entanto não
ultrapassa os valores de referência, já o Maf, na presença de anemia diminui, ficando
abaixo dos valores de referência. O LHD apresentou 34,2% de especificidade e 73,2% de
sensibilidade. O Maf apresentou 79,7% de especificidade e 56,9% de sensibilidade.
Concluiu-se que estes parâmetros podem ser usados para identificar situações de
ferropénia, em associação com os parâmetros já utlizados na prática clínica, sendo mais
um contributo para a identificação destas situações.
Iron deficiency anaemia affects thousands of people worldwide being the women the largest group of affected people. This form of anaemia is characterized by lack of iron in our organism due to a decreased consumption of iron in our diet, an increased consumption of iron by our metabolism or even in cases with high blood loss or chronic inflammation. The diagnosis of iron deficiency anaemia or even the iron deficiency alone is a tricky process as a result of the complexity characterized by iron metabolism. The identification of premature parameters of iron deficiency extremely important to prevent iron deficiency anemia. Thus, our goal with this project is to research the involvement of the new red blood cells parameters such as LHD and Maf, given by haematologic analyser Beckman Coulter DxH800, as previous markers of iron deficiency anaemia. To achieve this goal, we verified whether the new parameters provided by the Beckman Coulter DxH800 haematological equipment, specifically the low haemoglobin density and microcytic anemia factor, could be used as early parameters of iron deficiency anemia. Retrospectively we studied 367 samples between 2018 and 2019 from the immunohemotherapy appointment. A total of 190 (51,8%) samples were from females and 177 (48,2%) samples were from males. The majority of patients is between 35 and 65 years old, being the elderly (> 65 years old) the second age group most prevalent. The young adults represent only 11,7% of the study population. The samples were separated by anaemic or not anaemic in both sexes through haemoglobin (<12 g/dL in women and <13 g/dL in men). In a second stage, both sexes were separated by the value of ferritin (< 100 ng/mL) so we could form 2 distinct groups: with iron deficiency or without iron deficiency. About 30,0% of women and 41,% of men have iron deficiency. LHD is higher in people with anaemia than people without anaemia, however the values of LHD does not exceed the reference levels. Maf in the presence of anaemia has lower values, being above the reference levels. LHD has 34,2% of specificity and 73,2% sensibility. Maf has 79,7% of specificity and 56,9% of sensibility. In conclusion, these parameters have some differences between the groups, yet they cannot be considered as early parameters of iron deficiency anaemia. In conclusion this parameters can be used on clinical practice, being another assistance to identify these situations.
Iron deficiency anaemia affects thousands of people worldwide being the women the largest group of affected people. This form of anaemia is characterized by lack of iron in our organism due to a decreased consumption of iron in our diet, an increased consumption of iron by our metabolism or even in cases with high blood loss or chronic inflammation. The diagnosis of iron deficiency anaemia or even the iron deficiency alone is a tricky process as a result of the complexity characterized by iron metabolism. The identification of premature parameters of iron deficiency extremely important to prevent iron deficiency anemia. Thus, our goal with this project is to research the involvement of the new red blood cells parameters such as LHD and Maf, given by haematologic analyser Beckman Coulter DxH800, as previous markers of iron deficiency anaemia. To achieve this goal, we verified whether the new parameters provided by the Beckman Coulter DxH800 haematological equipment, specifically the low haemoglobin density and microcytic anemia factor, could be used as early parameters of iron deficiency anemia. Retrospectively we studied 367 samples between 2018 and 2019 from the immunohemotherapy appointment. A total of 190 (51,8%) samples were from females and 177 (48,2%) samples were from males. The majority of patients is between 35 and 65 years old, being the elderly (> 65 years old) the second age group most prevalent. The young adults represent only 11,7% of the study population. The samples were separated by anaemic or not anaemic in both sexes through haemoglobin (<12 g/dL in women and <13 g/dL in men). In a second stage, both sexes were separated by the value of ferritin (< 100 ng/mL) so we could form 2 distinct groups: with iron deficiency or without iron deficiency. About 30,0% of women and 41,% of men have iron deficiency. LHD is higher in people with anaemia than people without anaemia, however the values of LHD does not exceed the reference levels. Maf in the presence of anaemia has lower values, being above the reference levels. LHD has 34,2% of specificity and 73,2% sensibility. Maf has 79,7% of specificity and 56,9% of sensibility. In conclusion, these parameters have some differences between the groups, yet they cannot be considered as early parameters of iron deficiency anaemia. In conclusion this parameters can be used on clinical practice, being another assistance to identify these situations.
Description
Keywords
Anemia Ferro Low Haemoglobin Density Microcytic Anemia Factor Parâmetros