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Determining factors associated with inhaled therapy adherence on asthma and COPD: A systematic review and meta-analysis of the global literature

2021-12-21Journal article Open access
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dc.contributor.authorMonteiro, Constança Lourenço Pelicho
dc.contributor.authorMaricoto, Tiago
dc.contributor.authorPrazeres, José Filipe Chaves Pereira
dc.contributor.authorSimões, Pedro Augusto Gomes Rodrigues Marques
dc.contributor.authorSimões, José Augusto Rodrigues
dc.date.accessioned2021-12-27T11:41:14Z
dc.date.available2021-12-27T11:41:14Z
dc.date.issued2021-12-21
dc.description.abstractBackground Adherence to therapy has been reported worldwide as a major problem, and that is particularly relevant on inhaled therapy for Asthma and Chronic Obstructive Pulmonary Disease (COPD), considering its barriers and features. We reviewed the global literature reporting the main determinants for adherence on these patients. Methods Searches were made using the Cochrane Library, MEDLINE, EMBASE and ISI Web of Science databases. Analytical, observational and epidemiological studies (cohort, case-control and cross-sectional studies) were included, reporting association between any type of determinant and the adherence for inhaler therapy on Asthma or COPD. Random-effects meta-analysis were used to summarise the numerical effect estimates. Results 47 studies were included, including a total of 54.765 participants. In meta-analyses, the significant determinants of adherence to inhaled therapy were: older age [RR = 1.07 (1.03–1.10); I2 = 94; p < 0.0001] good disease knowledge/literacy [RR = 1.37 (1.28–1.47); I2 = 14; p = 0.33]; obesity [RR = 1.30 (1.12–1.50); I2 = 0; p = 0.37]; good cognitive performance [RR = 1.28 (1.17–1.40); I2 = 0; p = 0.62]; higher income [RR = 1.63 (1.05–2.56); I2 = 0; p = 0.52]; being employed [RR = 0.87 (0.83–0.90); I2 = 0; p = 0.76] and using multiple drugs/inhalers [RR = 0.81 (0.79–0.84); I2 = 0; p = 0.80]. Overall, the strength of the underlying evidence was only low to moderate. Conclusions Many determinants may be associated to patient's adherence, and personalised interventions should be taken in clinical practice to address it by gaining an understanding of their individual features.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMonteiro C, Maricoto T, Prazeres F, Simões PA, Simões JA. Determining factors associated with inhaled therapy adherence on asthma and COPD: A systematic review and meta-analysis of the global literature. Respiratory Medicine. 2022;191:106724.pt_PT
dc.identifier.doi10.1016/j.rmed.2021.106724pt_PT
dc.identifier.issn0954-6111
dc.identifier.urihttp://hdl.handle.net/10400.6/11507
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0954611121004327pt_PT
dc.subjectAdherencept_PT
dc.subjectInhaled therapypt_PT
dc.subjectCOPDpt_PT
dc.subjectAsthmapt_PT
dc.titleDetermining factors associated with inhaled therapy adherence on asthma and COPD: A systematic review and meta-analysis of the global literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106724pt_PT
oaire.citation.titleRespiratory Medicinept_PT
oaire.citation.volume191pt_PT
person.familyNameMaricoto
person.familyNamePrazeres
person.familyNameSimões
person.familyNameRodrigues Simões
person.givenNameTiago
person.givenNameFilipe
person.givenNamePedro Augusto
person.givenNameJosé Augusto
person.identifierR-00H-X7P
person.identifierL-4695-2016
person.identifier.ciencia-id1017-111B-5EF4
person.identifier.ciencia-idD91A-C347-7EF5
person.identifier.ciencia-id5111-BB0F-F1F2
person.identifier.ciencia-idE419-CED2-38BA
person.identifier.orcid0000-0002-4201-9565
person.identifier.orcid0000-0002-2849-5194
person.identifier.orcid0000-0003-4692-2003
person.identifier.orcid0000-0003-2264-7086
person.identifier.ridM-7423-2019
person.identifier.ridO-3955-2017
person.identifier.scopus-author-id56083702600
person.identifier.scopus-author-id36896116500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverya44e1933-35da-48a6-b1a2-616ddde66d92

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