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New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation

2014-10-16Journal article Restricted access
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dc.contributor.authorCarreira, Ana
dc.contributor.authorFerreira, Paula
dc.contributor.authorRibeiro, MP.
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCoutinho, Paula Isabel Teixeira Gonçalves
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGil, Maria
dc.date.accessioned2018-03-20T10:34:58Z
dc.date.available2018-03-20T10:34:58Z
dc.date.issued2014-10-16
dc.description.abstractCorneal tissue is the most commonly transplanted tissue worldwide. This work aimed to develop a new drug-eluting contact lens that may be used as a bandage after keratoprosthesis. During this work, films were produced using poly(vinyl alcohol) (PVA) and chitosan (CS) crosslinked with glyoxal (GL). Vancomycin chlorhydrate (VA) was impregnated in these systems by soaking. Attenuated total reflectance – Fourier transform infrared spectroscopy was used to confirm crosslinking. The cytotoxic and drug release profile, hydrophilicity, thermal and biodegradation as well as swelling capacity of the samples were assessed through in vitro studies. PVA and PVA/CS films were obtained by crosslinking with GL. The films were transparent, flexible with smooth surfaces, hydrophilic and able to load and release vancomycin for more than 8 h. Biodegradation in artificial lachrymal fluid (ALF) with lysozyme at 37 °C showed that mass loss was higher for the samples containing CS. Also, the samples prepared with CS showed the formation of pores which were visualized by SEM. All samples revealed a biocompatible character after 24 h in contact with cornea endothelial cells. As a general conclusion it was possible to determine that the 70PVA/30CS film showed to combine the necessary features to prepare vancomycin-eluting contact lenses to prevent inflammation after corneal substitution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarreira, A.S., Ferreira, P., Ribeiro, M.P., Correia, T.R., Coutinho, P., Correia, I.J. e Gil M.H. (2014) “New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation”, International Journal of Pharmaceutics, Vol. 477 (1-2), pp. 218-226pt_PT
dc.identifier.doi10.1016/j.ijpharm.2014.10.037pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4649
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517314007601#!pt_PT
dc.subjectDrug-eluting lenspt_PT
dc.subjectKeratoprosthesispt_PT
dc.subjectPoly(vinyl alcohol)pt_PT
dc.subjectChitosanpt_PT
dc.subjectGlyoxalpt_PT
dc.titleNew drug-eluting lenses to be applied as bandages after keratoprosthesis implantationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage226pt_PT
oaire.citation.startPage218pt_PT
oaire.citation.volume447pt_PT
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameRibeiro
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameGil
person.givenNamePaula
person.givenNameMaximiano
person.givenNameTiago
person.givenNameIlídio
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-0657-7751
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery3fe7a59f-e867-4bed-bb6e-7d7631330af5

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