New neo-Clerodanes fromTinnea antiscorbutica Welv

Borges, Cristina M. P.; Mendonça, Dina; Pinheiro, Sandra C. S.; Vieira, Liliana; Mendonça, António; Gaspar, Jorge F.; Martins, Célia; Diakanamwa, Carlos; Rueff, José

http://hdl.handle.net/10400.6/12306

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Authors

Borges, Cristina M. P.

Mendonça, Dina

Pinheiro, Sandra C. S.

Abstract(s)

Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 µg per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 µg /mL.

Keywords

Tinnea antiscorbutica Neo-clerodanes Mutagenic activity Cytotoxic activity Genotoxicity

URI

http://hdl.handle.net/10400.6/12306

Citation

Borges, C. M. P., De Mendonça, D. I. M. D., Pinheiro, S. C. S., Vieira, L., Mendonça, A. J. G., Gaspar, J. F., . . . Rueff, J. (2013). New neo-clerodanes from tinnea antiscorbutica welv. Journal of the Brazilian Chemical Society, 24(12), 1950-1956. doi:10.5935/0103-5053.20130244