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Orientador(es)
Resumo(s)
Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin), 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (penduletin) and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone (chrysosplenol D), were isolated from the methanol extract of Tinnea antiscorbutica. Antiscorbuticane B exhibited no mutagenic activity at doses of up to 250 µg per plate (Ames test) and did not induce micronucleus formation in the V79 cell line at doses of up to 100 µg /mL.
Descrição
Palavras-chave
Tinnea antiscorbutica Neo-clerodanes Mutagenic activity Cytotoxic activity Genotoxicity
Contexto Educativo
Citação
Borges, C. M. P., De Mendonça, D. I. M. D., Pinheiro, S. C. S., Vieira, L., Mendonça, A. J. G., Gaspar, J. F., . . . Rueff, J. (2013). New neo-clerodanes from tinnea antiscorbutica welv. Journal of the Brazilian Chemical Society, 24(12), 1950-1956. doi:10.5935/0103-5053.20130244
Editora
Brazilian Chemical Society