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IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion

2011-05Journal article Open access
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dc.contributor.authorCorreia, Margareta P.
dc.contributor.authorCosta, Alexandra V.
dc.contributor.authorUhrberg, Markus
dc.contributor.authorCardoso, Elsa M.
dc.contributor.authorArosa, FA
dc.date.accessioned2025-02-24T12:20:14Z
dc.date.available2025-02-24T12:20:14Z
dc.date.issued2011-05
dc.description.abstractDuring the last years several authors have described a small population of CD8+ T cells expressing NK receptors (NKRs). Although their origin remains largely unknown, we have recently demonstrated that IL-15 is capable of inducing NKR expression in purified human CD8+CD56− T cells. In this study we show that IL-15-driven NKR induction in CD8+ T cells was linked with CD56 de novo acquisition, consistent with an effector-memory phenotype, increased anti-apoptotic levels, high granzyme B/perforin expression and with the ability of displaying in vitro NK-like cytotoxicity. Interestingly, dissection of NKR functional outcome in IL-15-cultured CD8+ T cells revealed: (i) that NKG2D cross-linking was able per se to upregulate degranulation levels and (ii) that KIR and NKG2A cross-linking upregulated secretion of cytokines such as IFN-, TNF-, IL-1 and IL-10. These results suggest that IL-15 is capable of differentiating CD8+ T cells into NK-like T cells displaying a regulatory phenotype.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.imbio.2010.09.012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/15122
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIL-15 TRANS-PRESENTATION BY HEPATOMA CELLS: IMPLICATIONS FOR CD8+ T CELL DIFFERENTIATION AND FUNCTION
dc.subjectCD8+ T cellspt_PT
dc.subjectCytokinespt_PT
dc.subjectDifferentiationpt_PT
dc.subjectIL-15pt_PT
dc.subjectNK receptorspt_PT
dc.titleIL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIL-15 TRANS-PRESENTATION BY HEPATOMA CELLS: IMPLICATIONS FOR CD8+ T CELL DIFFERENTIATION AND FUNCTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBD%2F24396%2F2005/PT
oaire.citation.endPage612pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage604pt_PT
oaire.citation.titleImmunobiologypt_PT
oaire.citation.volume216pt_PT
oaire.fundingStreamPIDDAC
person.familyNameCorreia
person.familyNameUhrberg
person.familyNamePereira de Oliveira Cardoso
person.familyNameArosa
person.givenNameMargareta
person.givenNameMarkus
person.givenNameElsa Maria
person.givenNameFernando
person.identifier42163
person.identifierAAL-5774-2020
person.identifier83032
person.identifier.ciencia-id3D1D-5BC2-1E48
person.identifier.ciencia-id451A-408C-36AB
person.identifier.orcid0000-0003-4378-0820
person.identifier.orcid0000-0001-9553-1987
person.identifier.orcid0000-0002-6937-6474
person.identifier.orcid0000-0002-7209-4507
person.identifier.ridE-5640-2010
person.identifier.scopus-author-id6604045863
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication518199fc-bed6-423a-95dd-e7d950024540
relation.isAuthorOfPublication08971be3-8f9f-42c6-aa55-ac18f9afceae
relation.isAuthorOfPublication605c7abc-01ef-46a8-8b3e-4b2dedaaa239
relation.isAuthorOfPublication21581c53-bb88-4c42-a41a-911215411178
relation.isAuthorOfPublication.latestForDiscovery08971be3-8f9f-42c6-aa55-ac18f9afceae
relation.isProjectOfPublication17b917fb-69ad-408b-ba05-99c9f0961620
relation.isProjectOfPublication.latestForDiscovery17b917fb-69ad-408b-ba05-99c9f0961620

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