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Advisor(s)
Abstract(s)
Background Very few prior studies have investigated the presence of ascites as a prognostic factor in children with cirrhosis.
To the best of our knowledge, there are no prior studies evaluating the relationship between severity of ascites and patient
survival in children with biliary atresia and cirrhosis.
Aims To evaluate the association between severity of ascites and survival of children with cirrhosis and biliary atresia.
Methods All children with cirrhosis secondary to biliary atresia evaluated at our institution from 2000 to 2014 were included
in this study. Patients were classified into four groups: NA = no ascites; A1 = grade 1 ascites; A2 = grade 2 ascites; and
A3 = grade 3 ascites. The primary endpoint of the study was mortality within the first year after patient inclusion. Ninetyday
mortality was also evaluated. Prognostic factors related to both endpoints also were studied. [...]
Description
Very few prior studies have investigated the presence of ascites as a prognostic factor in children with cirrhosis. To the best of our knowledge, there are no prior studies evaluating the relationship between severity of ascites and patient survival in children with biliary atresia and cirrhosis.Clinically detectable ascites is associated with decreased 1-year survival of children with biliary atresia. These patients should be treated with caution and prioritized for liver transplantation.
Keywords
Ascites Chronic liver disease Liver transplant Pediatric patients Portal hypertension Survival