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Injectable in situ forming hydrogels incorporating dual-nanoparticles for chemo- photothermal therapy of breast cancer cells

2021-03-17Journal article Open access
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dc.contributor.authorSabino, Ivo
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorAlves, Cátia
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorDiogo, Duarte de Melo
dc.date.accessioned2021-03-23T11:58:19Z
dc.date.available2023-03-23T01:30:21Z
dc.date.issued2021-03-17
dc.description.abstractChemo-photothermal therapy (chemo-PTT) mediated by nanomaterials holds a great potential for cancer treatment. However, the tumor uptake of the systemically administered nanomaterials was recently found to be below 1 %. To address this limitation, the development of injectable tridimensional polymeric matrices capable of delivering nanomaterials directly into the tumor site appears to be a promising approach. In this work, an injectable in situ forming ionotropically crosslinked chitosan-based hydrogel co-incorporating IR780 loaded nanoparticles (IR/BPN) and Doxorubicin (DOX) loaded nanoparticles (DOX/TPN) was developed for application in breast cancer chemo-PTT. The produced hydrogels (IR/BPN@Gel and IR/BPN+DOX/TPN@Gel) displayed suitable physicochemical properties and produced a temperature increase of about 9.1 °C upon exposure to Near Infrared (NIR) light. As importantly, the NIR-light exposure also increased the release of DOX from the hydrogel by 1.7-times. In the in vitro studies, the combination of IR/BPN@Gel with NIR light (photothermal therapy) led to a reduction in the viability of breast cancer cells to 35 %. On the other hand, the non-irradiated IR/BPN+DOX/TPN@Gel (chemotherapy) only diminished cancer cells' viability to 85 %. In contrast, the combined action of IR/BPN+DOX/TPN@Gel and NIR light reduced cancer cells' viability to about 9 %, demonstrating its potential for breast cancer chemo-PTTpt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2021.120510pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11125
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S037851732100315Xpt_PT
dc.subjectLocalized Deliverypt_PT
dc.subjectIR780pt_PT
dc.subjectInjectable Hydrogelpt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectCancer Chemo-Photothermal Therapypt_PT
dc.titleInjectable in situ forming hydrogels incorporating dual-nanoparticles for chemo- photothermal therapy of breast cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.titleInternational Journal of pharmaceuticspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameSabino
person.familyNameSousa
person.familyNameAlves
person.familyNameLopes Melo
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameIvo
person.givenNameAna Rita Lima
person.givenNameCátia Gomes
person.givenNameBruna Daniela
person.givenNameAndré Ferreira
person.givenNameIlídio
person.givenNameDuarte
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifierC2z5x04AAAAJ
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-id5717-CB52-B4E5
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.orcid0000-0002-9185-2342
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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