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Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regeneration

2024-01-05Journal article Open access
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dc.contributor.authorCabral, Cátia S. D.
dc.contributor.authorMelo-Diogo, Duarte de
dc.contributor.authorFerreira, Paula
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2024-03-25T14:57:40Z
dc.date.available2024-03-25T14:57:40Z
dc.date.issued2024-01-05
dc.description.abstractBone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic the bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined with drug delivery and phototherapy. Herein, a Fab@Home 3D Plotter printer was used to promote the layer-by-layer deposition of a composite mixture of gelatin, chitosan, tricalcium phosphate, and reduced graphene oxide (rGO). The phototherapeutic potential of the new NIR-responsive 3D_rGO scaffolds was assessed by comparing scaffolds with different rGO concentrations (1, 2, and 4 mg/mL). The data obtained show that the rGO incorporation confers to the scaffolds the capacity to interact with NIR light and induce a hyperthermy effect, with a maximum temperature increase of 16.7 °C after under NIR irradiation (10 min). Also, the increase in the rGO content improved the hydrophilicity and mechanical resistance of the scaffolds, particularly in the 3D_rGO4. Furthermore, the rGO could confer an NIR-triggered antibacterial effect to the 3D scaffolds, without compromising the osteoblasts' proliferation and viability. In general, the obtained data support the development of 3D_rGO for being applied as temporary scaffolds supporting the new bone tissue formation and avoiding the establishment of bacterial infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijbiomac.2024.129210pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/14317
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationBiomimetic 3D scaffolds coated with a thermo-responsive hydrogel containing smart pharmaceuticals nanocarriers aimed for bone tissue regeneration
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813024000138#ab0015pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subject3D scaffoldspt_PT
dc.subjectBone tissue engineeringpt_PT
dc.subjectRapid prototypingpt_PT
dc.subjectChitosanpt_PT
dc.subjectReduced graphene oxidept_PT
dc.subjectNear-infrared radiationpt_PT
dc.titleReduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleBiomimetic 3D scaffolds coated with a thermo-responsive hydrogel containing smart pharmaceuticals nanocarriers aimed for bone tissue regeneration
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.06320.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151024%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.startPage129210pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume259pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC IND4ed
person.familyNameCabral
person.familyNameMiguel de Melo Diogo
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameCátia Solange Duarte
person.givenNameDuarte
person.givenNamePaula
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8D18-367B-2572
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person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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