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Browsing by Issue Date, starting with "2024-01-05"

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  • Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regeneration
    Publication . Cabral, Cátia S. D.; Melo-Diogo, Duarte de; Ferreira, Paula; Moreira, André F.; Correia, I.J.
    Bone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic the bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined with drug delivery and phototherapy. Herein, a Fab@Home 3D Plotter printer was used to promote the layer-by-layer deposition of a composite mixture of gelatin, chitosan, tricalcium phosphate, and reduced graphene oxide (rGO). The phototherapeutic potential of the new NIR-responsive 3D_rGO scaffolds was assessed by comparing scaffolds with different rGO concentrations (1, 2, and 4 mg/mL). The data obtained show that the rGO incorporation confers to the scaffolds the capacity to interact with NIR light and induce a hyperthermy effect, with a maximum temperature increase of 16.7 °C after under NIR irradiation (10 min). Also, the increase in the rGO content improved the hydrophilicity and mechanical resistance of the scaffolds, particularly in the 3D_rGO4. Furthermore, the rGO could confer an NIR-triggered antibacterial effect to the 3D scaffolds, without compromising the osteoblasts' proliferation and viability. In general, the obtained data support the development of 3D_rGO for being applied as temporary scaffolds supporting the new bone tissue formation and avoiding the establishment of bacterial infections.
    2024-01-05Journal article Open access Show more
  • UBI Journey: Promovendo a Socialização Estudantil e a Exploração da Covilhã
    Publication . Santos, João Braga; Silva, Bruno Miguel Correia da; Alves, Helena Maria Baptista
    Esta dissertação aborda a criação de um jogo mobile, intitulado UBI Journey, com o propósito de aprimorar a experiência universitária dos estudantes na UBI. O projeto busca promover a socialização entre os alunos, explorando tanto os recursos da instituição quanto as características da cidade da Covilhã, Portugal. A dissertação apresenta uma análise detalhada dos benefícios do UBI Journey, ressaltando como a integração social e a exploração são elementos-chave para enriquecer a vivência estudantil. O trabalho também discute a construção prática do jogo, explorando aspectos técnicos e de design, além de abordar diferentes abordagens e ferramentas utilizadas para sua implementação. Ao final, a pesquisa visa contribuir com um modelo que pode ser aplicado em outras instituições universitárias, visando melhorar a integração e socialização dos alunos.
    2024-01-05Master thesis Open access Show more