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D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

2017-02-09Journal article Restricted access
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dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorSilva, Cleide Isabel Pais
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorLouro, Ricardo
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-22T08:57:29Z
dc.date.available2018-03-22T08:57:29Z
dc.date.issued2017-02-09
dc.description.abstractAim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells’ viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationde Melo-Diogo, D., Pais-Silva, C., Costa, E. C. e Correia, I. J (2017) “D-alpha-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy.” Nanomedicine, Vol.12 (5), pp. 443-456pt_PT
dc.identifier.doi10.2217/nnm-2016-0384pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4694
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Medicinept_PT
dc.relationHealth Sciences Research Centre
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.futuremedicine.com/doi/abs/10.2217/nnm-2016-0384pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectNanographene oxidept_PT
dc.subjectPEGylated Vitamin Ept_PT
dc.subjectPhototherapypt_PT
dc.subjectTPGSpt_PT
dc.titleD-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.endPage456pt_PT
oaire.citation.startPage443pt_PT
oaire.citation.titleNanomedicinept_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMiguel de Melo Diogo
person.familyNameda Rocha Costa
person.familyNameLouro
person.familyNameJoaquim Sobreira Correia
person.givenNameDuarte
person.givenNameElisabete Cristina
person.givenNameRicardo
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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