D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

Diogo, Duarte Miguel de Melo; Silva, Cleide Isabel Pais; Costa, Elisabete C.; Louro, Ricardo; Correia, Ilídio Joaquim Sobreira

http://hdl.handle.net/10400.6/4694

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Authors

Diogo, Duarte Miguel de Melo

Silva, Cleide Isabel Pais

Costa, Elisabete C.

Louro, Ricardo

Correia, Ilídio Joaquim Sobreira

Abstract(s)

Aim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells’ viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.

Keywords

Breast cancer Nanographene oxide PEGylated Vitamin E Phototherapy TPGS

URI

http://hdl.handle.net/10400.6/4694

Citation

de Melo-Diogo, D., Pais-Silva, C., Costa, E. C. e Correia, I. J (2017) “D-alpha-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy.” Nanomedicine, Vol.12 (5), pp. 443-456