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Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

2018Journal article Open access
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dc.contributor.authorMonteiro, João
dc.contributor.authorAlves, Marco G
dc.contributor.authorOliveira, P.F.
dc.contributor.authorSilva, Branca M.
dc.date.accessioned2020-02-14T16:54:30Z
dc.date.available2020-02-14T16:54:30Z
dc.date.issued2018
dc.description.abstractMethylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. The supposedly relatively low toxicity of methylxanthines, combined with the many beneficial effects that have been attributed to these compounds through time, generated a justified attention and a very prolific ground for dedicated scientific reports. Methylxanthines have been widely used as therapeutical tools, in an intriguing range of medicinal scopes. In fact, methylxanthines have been/were medically used as Central Nervous System stimulants, bronchodilators, coronary dilators, diuretics and anti-cancer adjuvant treatments. Other than these applications, methylxanthines have also been hinted to hold other beneficial health effects, namely regarding neurodegenerative diseases, cardioprotection, diabetes and fertility. However, it seems now consensual that toxicity concerns related to methylxanthine consumption and/or therapeutic use should not be dismissed. Taking all the knowledge and expectations on the potential of methylxanthines into account, we propose a systematic look at the past and future of methylxanthine pharmacologic applications, discussing all the promise and anticipating possible constraints. Anyways, methylxanthines will still substantiate considerable meaningful research and discussion for years to come.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/10408398.2018.1461607pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9275
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationObesitility – Leptin-ghrelin axis and testicular metabolism: mechanisms associated with obesity-related male infertility
dc.subjectHistory 20th Centurypt_PT
dc.subjectXanthinespt_PT
dc.subjectHumanspt_PT
dc.subjectRetrospective Studiespt_PT
dc.titlePharmacological potential of methylxanthines: Retrospective analysis and future expectationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleObesitility – Leptin-ghrelin axis and testicular metabolism: mechanisms associated with obesity-related male infertility
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F108837%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBBB-BQB%2F1368%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F80451%2F2011/PT
oaire.citation.endPage2625pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage2597pt_PT
oaire.citation.titleCritical Reviews in Food Science and Nutritionpt_PT
oaire.citation.volume59pt_PT
oaire.fundingStream5876
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamSFRH
person.familyNameAlves
person.familyNameOliveira
person.familyNameSilva
person.givenNameMarco G.
person.givenNamePedro Fontes
person.givenNameBranca Maria
person.identifier2358493
person.identifier1033309
person.identifier.ciencia-id7915-53C7-40C2
person.identifier.ciencia-id9F16-B704-C407
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.orcid0000-0001-7635-783X
person.identifier.orcid0000-0002-4989-5699
person.identifier.orcid0000-0002-5610-8024
person.identifier.ridG-4795-2010
person.identifier.scopus-author-id57202054274
person.identifier.scopus-author-id36198848500
person.identifier.scopus-author-id7005615589
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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