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Interferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell subset and plasmablasts

2018-11-18Journal article Open access
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dc.contributor.authorMonteiro, Andreia
dc.contributor.authorCruto, Catarina
dc.contributor.authorRosado, Pedro
dc.contributor.authorRosado, Luiza
dc.contributor.authorFonseca, Ana Mafalda
dc.contributor.authorPaiva, Artur
dc.date.accessioned2019-11-07T16:57:13Z
dc.date.available2019-11-07T16:57:13Z
dc.date.issued2018-11-18
dc.description.abstractOur aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27- and CD27+ memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27- and CD27+IgM+ memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jneuroim.2018.11.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7537
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCD27pt_PT
dc.subjectImmature/transitional B cell subsetpt_PT
dc.subjectPlasmablastpt_PT
dc.subjectRelapsing-remitting multiple sclerosispt_PT
dc.titleInterferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell subset and plasmablastspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage54pt_PT
oaire.citation.startPage49pt_PT
oaire.citation.titleJournal of Neuroimmunologypt_PT
oaire.citation.volume326pt_PT
oaire.fundingStream5876
person.familyNameLoureiro Fonseca
person.familyNamePaiva
person.givenNameAna Mafalda
person.givenNameArtur
person.identifierH-3836-2012
person.identifier.ciencia-idA61D-657A-6DD0
person.identifier.ciencia-id7E14-DBD6-0EC3
person.identifier.orcid0000-0003-1118-5525
person.identifier.orcid0000-0002-6562-5859
person.identifier.scopus-author-id7102683751
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication34cfbd2d-5537-4aba-8552-3e2e4d48b473
relation.isAuthorOfPublication94d1b83f-d40d-4e26-be89-ed393fe70f5f
relation.isAuthorOfPublication.latestForDiscovery94d1b83f-d40d-4e26-be89-ed393fe70f5f
relation.isProjectOfPublicationcb4688cf-40da-4197-9eb0-c55bad699ad3
relation.isProjectOfPublication.latestForDiscoverycb4688cf-40da-4197-9eb0-c55bad699ad3

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