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Advisor(s)
Abstract(s)
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data continuously emerging,
regarding their diverse types, applications, and roles. Particular attention has been given to ncRNA with regulatory functions, which may have a critical role both in biological and pathological conditions. As a result of the
diversity of ncRNAs and their ubiquitous involvement in several biologic processes, ncRNA started to be
considered in the biomedical field, with immense potential to be exploited either as biomarkers or as therapeutic
agents in certain pathologies. Indeed, ncRNA-based therapeutics have been proposed in many disorders and some
even reached clinical trials. However, to prepare an RNA product suitable for pharmacological applications,
certain criteria must be fulfilled, and it has to be guaranteed RNA purity, stability, and bioactivity. So, in this
review, the different types of ncRNAs are identified and characterized, by describing their biogenesis, functions,
and applications. A perspective on the main challenges and innovative approaches for the future and broad
therapeutic application of RNA is also presented.
Description
Keywords
ncRNA Biological activity Therapeutic application Diagnosis