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Non-coding RNAs: Emerging from the discovery to therapeutic applications

2021-02-10Journal article Restricted access
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dc.contributor.authorBaptista, Bruno
dc.contributor.authorRiscado, Micaela
dc.contributor.authorQueiroz, João
dc.contributor.authorPichon, Chantal
dc.contributor.authorSousa, F.
dc.date.accessioned2025-02-24T17:15:23Z
dc.date.available2025-02-24T17:15:23Z
dc.date.issued2021-02-10
dc.description.abstractThe knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data continuously emerging, regarding their diverse types, applications, and roles. Particular attention has been given to ncRNA with regulatory functions, which may have a critical role both in biological and pathological conditions. As a result of the diversity of ncRNAs and their ubiquitous involvement in several biologic processes, ncRNA started to be considered in the biomedical field, with immense potential to be exploited either as biomarkers or as therapeutic agents in certain pathologies. Indeed, ncRNA-based therapeutics have been proposed in many disorders and some even reached clinical trials. However, to prepare an RNA product suitable for pharmacological applications, certain criteria must be fulfilled, and it has to be guaranteed RNA purity, stability, and bioactivity. So, in this review, the different types of ncRNAs are identified and characterized, by describing their biogenesis, functions, and applications. A perspective on the main challenges and innovative approaches for the future and broad therapeutic application of RNA is also presented.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.bcp.2021.114469pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/15127
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0006295221000654?via%3Dihubpt_PT
dc.subjectncRNApt_PT
dc.subjectBiological activitypt_PT
dc.subjectTherapeutic applicationpt_PT
dc.subjectDiagnosispt_PT
dc.titleNon-coding RNAs: Emerging from the discovery to therapeutic applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBII-BBF%2F29496%2F2017/PT
oaire.citation.startPage114469pt_PT
oaire.citation.titleBiochemical Pharmacologypt_PT
oaire.citation.volume189pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
person.familyNameBaptista
person.familyNameRibeiro Riscado
person.familyNameQueiroz
person.familyNameSousa
person.givenNameBruno
person.givenNameMicaela Sofia
person.givenNameJoão
person.givenNameFani
person.identifier1755257
person.identifier.ciencia-id6017-6EF6-6B91
person.identifier.ciencia-id2715-8A41-431B
person.identifier.ciencia-id931E-B66D-E341
person.identifier.ciencia-id991D-2E13-A840
person.identifier.orcid0000-0001-8539-5395
person.identifier.orcid0000-0002-7367-0748
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-9996-2194
person.identifier.ridL-3104-2014
person.identifier.ridA-2014-2017
person.identifier.scopus-author-id57222082381
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id7005110268
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofct© 2021 Elsevier Inc. All rights reserved.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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