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Authors
Abstract(s)
A insuficiência cardíaca (IC) é uma importante entidade de saúde pública a nível
global, relacionável com o incremento de mortalidade cardiovascular global. É crucial
que haja uma boa gestão desta síndrome, de modo a reduzir hospitalizações recorrentes
devido a descompensações, que promovem um agravamento clínico acelerado, pioram
a qualidade de vida dos doentes e acarretam custos económicos crescentes. A
telemonitorização, aliada a ferramentas como o Point-Of-Care testing (POCT), poderão
ser armas importantes a utilizar neste contexto. A saliva é um fluído passível de ser
recolhido através de métodos não invasivos, que poderá ser utilizado na
telemonitorização da IC, caso seja validada a medição de biomarcadores cardíacos
neste meio.
Neste trabalho, é descrito o protocolo experimental de um estudo de comparação
entre as concentrações plasmáticas e salivares da molécula NT-proBNP, amplamente
utilizada na prática clínica no contexto da IC, para fins de diagnóstico, monitorização e
estratificação de risco. O objetivo do estudo é perceber se existe ou não uma correlação
significativa entre estes dois conjuntos de valores, contudo este não foi concluído na
sua totalidade até à data de escrita deste trabalho, devido à falta de dados da análise
salivar de NT-proBNP, por limitação não imputável á autora.
Futuramente, com o término deste projeto de investigação e o surgimento de um
maior volume de estudos neste âmbito, poderá ser possível proceder à validação deste
biomarcador na saliva. Com isto em mente, seria proveitosa a criação de um dispositivo
capaz de quantificar as concentrações salivares de NT-proBNP, apropriado para
utilização em contexto de telemonitorização com recurso a POCT.
Heart failure (HF) is an important public health entity worldwide, related to the increase in global cardiovascular mortality. It is crucial to have a good management of this syndrome in order to reduce recurrent hospitalisations due to decompensations, which promote an accelerated clinical worsening, worsen the quality of life of patients and entail increasing economic costs. Telemonitoring, together with tools such as Point-Of-Care testing (POCT), may be important weapons to be used in this context. Saliva is a fluid that can be collected through non-invasive methods, which may be used in HF telemonitoring, if the measurement of cardiac biomarkers in this medium is validated. In this paper, the experimental protocol of a study comparing plasma and salivary concentrations of the NT-proBNP molecule is described, one widely used in clinical practice in the context of HF, for diagnosis, monitoring and risk stratification purposes. The aim of the study is to understand whether or not there is a significant correlation between these two sets of values, however this was not fully completed by the time of writing this paper, due to the lack of data from the salivary analysis of NT-proBNP, due to a limitation not attributable to the author. In the future, with the conclusion of this research project and the emergence of a greater volume of studies in this area, it may be possible to validate this biomarker in saliva. With this in mind, it would be useful to create a device capable of quantifying the salivary concentrations of NT-proBNP, suitable for use in the context of telemonitoring using POCT.
Heart failure (HF) is an important public health entity worldwide, related to the increase in global cardiovascular mortality. It is crucial to have a good management of this syndrome in order to reduce recurrent hospitalisations due to decompensations, which promote an accelerated clinical worsening, worsen the quality of life of patients and entail increasing economic costs. Telemonitoring, together with tools such as Point-Of-Care testing (POCT), may be important weapons to be used in this context. Saliva is a fluid that can be collected through non-invasive methods, which may be used in HF telemonitoring, if the measurement of cardiac biomarkers in this medium is validated. In this paper, the experimental protocol of a study comparing plasma and salivary concentrations of the NT-proBNP molecule is described, one widely used in clinical practice in the context of HF, for diagnosis, monitoring and risk stratification purposes. The aim of the study is to understand whether or not there is a significant correlation between these two sets of values, however this was not fully completed by the time of writing this paper, due to the lack of data from the salivary analysis of NT-proBNP, due to a limitation not attributable to the author. In the future, with the conclusion of this research project and the emergence of a greater volume of studies in this area, it may be possible to validate this biomarker in saliva. With this in mind, it would be useful to create a device capable of quantifying the salivary concentrations of NT-proBNP, suitable for use in the context of telemonitoring using POCT.
Description
Keywords
Biomarcadores Insuficiência Cardíaca Nt-Probnp Saliva Telemonitorização