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Abstract(s)
Este relatĂłrio para a obtenção do tĂtulo de mestre em CiĂȘncias FarmacĂȘuticas estĂĄ
estruturado em dois capĂtulos: o CapĂtulo 1 apresenta uma revisĂŁo bibliogrĂĄfica sobre
as aplicaçÔes terapĂȘuticas de fĂĄrmacos que visam as cĂ©lulas senescentes em doenças
cerebrais, enquanto o CapĂtulo 2 detalha experiĂȘncias profissionais em FarmĂĄcia
ComunitĂĄria.
O CapĂtulo 1 explora âSenescĂȘncia Celular: Perspetivas TerapĂȘuticas para Doenças
Neurodegenerativasâ. Numa população global cada vez mais idosa, a longevidade
reflete avanços na tecnologia e na saĂșde, mas tambĂ©m apresenta desafios significativos.
Acrescentar anos Ă vida nĂŁo melhora necessariamente a qualidade de vida,
especialmente porque o envelhecimento é frequentemente acompanhado por doenças
complexas relacionadas com a idade. A senescĂȘncia celular, um processo biolĂłgico
fundamental para o desenvolvimento, mas prejudicial no envelhecimento, estĂĄ
intimamente ligada a vĂĄrias doenças relacionadas Ă idade, tornando-se um mecanismochave no processo de envelhecimento. Portanto, compreender as caracterĂsticas
distintas das cĂ©lulas senescentes Ă© crucial para desenvolver estratĂ©gias terapĂȘuticas
eficazes. Ao explorar a interseção de "envelhecimento biolĂłgico - senescĂȘncia celular -
doenças neurodegenerativas", a comunidade cientĂfica tem-se concentrado em
investigar os potenciais benefĂcios da eliminação seletiva de cĂ©lulas senescentes para
melhorar a saĂșde e o bem-estar dos idosos. Atualmente, as abordagens terapĂȘuticas
direcionadas Ă senescĂȘncia celular podem ser categorizadas em duas estratĂ©gias
farmacolĂłgicas distintas: intervençÔes senolĂticas de 1ÂȘ geração e senomĂłrficas. Esta
pesquisa concentra-se na revisĂŁo das aplicaçÔes terapĂȘuticas de compostos
selecionados - especificamente a combinação senolĂtica de Dasatinibe e Quercetina, e
Navitoclax, juntamente com agentes senomĂłrficos como Metformina e Rapamicina - no
contexto de doenças neurodegenerativas e declĂnio cognitivo. Ensaios prĂ©-clĂnicos tĂȘm
demonstrado potencial eficĂĄcia dessas terapias, indicando resultados promissores das
mesmas no tratamento de doenças relacionadas Ă idade. No entanto, os ensaios clĂnicos
em andamento estĂŁo predominantemente nas fases I/II, exigindo estudos adicionais
abrangentes e randomizados para validar as evidĂȘncias acumuladas. Em conclusĂŁo, as
intervençÔes senolĂticas e senomĂłrficas representam estratĂ©gias farmacolĂłgicas
versĂĄteis e promissoras para abordar doenças neurodegenerativas associadas Ă
senescĂȘncia celular. O CapĂtulo 2 Ă© dedicado ao relatĂłrio de estĂĄgio que detalha a experiĂȘncia profissional
no contexto da FarmĂĄcia ComunitĂĄria na FarmĂĄcia Ribeirabravense. Este descreve o
fluxo de medicamentos e de diversos produtos de saĂșde, referindo o papel ativo e
multifacetado do farmacĂȘutico comunitĂĄrio atravĂ©s de experiĂȘncias documentadas.
Esta experiĂȘncia em primeira mĂŁo enfatiza as responsabilidades assumidas pelos
farmacĂȘuticos comunitĂĄrios.
This report for the masterâs degree in Pharmaceutical Sciences is structured into two chapters: Chapter 1 reports a bibliographic revision about the therapeutic applications of drugs targeting senescent cells for brain diseases, while Chapter 2 details professional experiences in Community Pharmacy. Chapter 1 explores âCellular Senescence: Therapeutic Perspectives for Neurodegenerative Diseasesâ. In an increasingly elderly global population, longevity reflects advancements in technology and healthcare, yet it also presents significant challenges. Adding years to life does not inherently improve quality of life, especially as aging is often accompanied by complex age-related diseases. Cellular senescence, a biological process integral to development yet detrimental in aging, is closely linked to various age-related diseases, making it a key mechanism in the aging process. As a result, understanding the distinct characteristics of senescent cells is crucial for developing effective therapeutic strategies. By exploring the intersection of "biological aging - cellular senescence - neurodegenerative diseases", the scientific community has focused on investigating the potential benefits of selectively eliminating senescent cells to enhance the health and well-being of the elderly. Currently, therapeutic approaches targeting cellular senescence can be categorized into two distinct pharmacological strategies: 1st gerenation senolytic and senomorphic interventions. This research focuses on the review of the therapeutic applications of selected compoundsâ specifically, the senolytic combination Dasatinib, Quercetin and Navitoclax alongside the senomorphic agents such as, Metformin and Rapamycinâin the context of neurodegenerative diseases and cognitive decline. Pre-clinical trials have demonstrated the potential efficacy of these age-specific therapies, indicating promising outcomes in age-related disease management. Nevertheless, ongoing clinical trials are predominantly in phase I/II stages, requiring further comprehensive and randomized studies. In conclusion, senolytic and senomorphic interventions represent versatile and promising pharmacological strategies for addressing neurodegenerative diseases associated with cellular senescence. Chapter 2 is devoted to the internship report detailing the professional experience in the realm of Community Pharmacy at FarmĂĄcia Ribeirabravense. It outlines the flow of medications and diverse health products, illustrating the active and multifaceted role of the community pharmacist through lived and documented experiences. This firsthand experience underscores the dynamic and multifaceted responsibilities undertaken by community pharmacists.
This report for the masterâs degree in Pharmaceutical Sciences is structured into two chapters: Chapter 1 reports a bibliographic revision about the therapeutic applications of drugs targeting senescent cells for brain diseases, while Chapter 2 details professional experiences in Community Pharmacy. Chapter 1 explores âCellular Senescence: Therapeutic Perspectives for Neurodegenerative Diseasesâ. In an increasingly elderly global population, longevity reflects advancements in technology and healthcare, yet it also presents significant challenges. Adding years to life does not inherently improve quality of life, especially as aging is often accompanied by complex age-related diseases. Cellular senescence, a biological process integral to development yet detrimental in aging, is closely linked to various age-related diseases, making it a key mechanism in the aging process. As a result, understanding the distinct characteristics of senescent cells is crucial for developing effective therapeutic strategies. By exploring the intersection of "biological aging - cellular senescence - neurodegenerative diseases", the scientific community has focused on investigating the potential benefits of selectively eliminating senescent cells to enhance the health and well-being of the elderly. Currently, therapeutic approaches targeting cellular senescence can be categorized into two distinct pharmacological strategies: 1st gerenation senolytic and senomorphic interventions. This research focuses on the review of the therapeutic applications of selected compoundsâ specifically, the senolytic combination Dasatinib, Quercetin and Navitoclax alongside the senomorphic agents such as, Metformin and Rapamycinâin the context of neurodegenerative diseases and cognitive decline. Pre-clinical trials have demonstrated the potential efficacy of these age-specific therapies, indicating promising outcomes in age-related disease management. Nevertheless, ongoing clinical trials are predominantly in phase I/II stages, requiring further comprehensive and randomized studies. In conclusion, senolytic and senomorphic interventions represent versatile and promising pharmacological strategies for addressing neurodegenerative diseases associated with cellular senescence. Chapter 2 is devoted to the internship report detailing the professional experience in the realm of Community Pharmacy at FarmĂĄcia Ribeirabravense. It outlines the flow of medications and diverse health products, illustrating the active and multifaceted role of the community pharmacist through lived and documented experiences. This firsthand experience underscores the dynamic and multifaceted responsibilities undertaken by community pharmacists.
Description
Keywords
Doenças
Neurodegenerativas Envelhecimento SenescĂȘncia Celular SenolĂtos SenomĂłrficos