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Cell‐Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enhanced Blood Circulation and Cancer Therapy

2022-10-17Journal article Open access
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dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorFernandes, Natanael
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorCorreia, I.J.
dc.contributor.authorMoreira, André F.
dc.date.accessioned2023-01-03T16:03:52Z
dc.date.available2023-01-03T16:03:52Z
dc.date.issued2022-10-17
dc.description.abstractCancer nanomedicines are designed to encapsulate different therapeuticagents, prevent their premature release, and deliver them specifically tocancer cells, due to their ability to preferentially accumulate in tumor tissue.However, after intravenous administration, nanoparticles immediatelyinteract with biological components that facilitate their recognition by theimmune system, being rapidly removed from circulation. Reports show thatless than 1% of the administered nanoparticles effectively reach the tumorsite. This suboptimal pharmacokinetic profile is pointed out as one of themain factors for the nanoparticles’ suboptimal therapeutic effectiveness andpoor translation to the clinic. Therefore, an extended blood circulation timemay be crucial to increase the nanoparticles’ chances of being accumulated inthe tumor and promote a site-specific delivery of therapeutic agents. For thatpurpose, the understanding of the forces that govern the nanoparticles’interaction with biological components and the impact of the physicochemicalproperties on the in vivo fate will allow the development of novel and moreeffective nanomedicines. Therefore, in this review, the nano–bio interactionsare summarized. Moreover, the application of cell-derived vesicles forextending the blood circulation time and tumor accumulation is reviewed,focusing on the advantages and shortcomings of each cell source.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/adhm.202201214pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12578
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherwileypt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBlood circulationpt_PT
dc.subjectCancerpt_PT
dc.subjectCell-derived vesiclespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectProteincoronapt_PT
dc.subjectStealthingpt_PT
dc.titleCell‐Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enhanced Blood Circulation and Cancer Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.citation.conferencePlaceEUApt_PT
oaire.citation.issue23pt_PT
oaire.citation.startPage2201214pt_PT
oaire.citation.titleAdvanced Healthcare Materialspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND4ed
person.familyNameFélix Rodrigues
person.familyNameFernandes
person.familyNameMiguel de Melo Diogo
person.familyNameJoaquim Sobreira Correia
person.familyNameMoreira
person.givenNameAna Carolina
person.givenNameNatanael
person.givenNameDuarte
person.givenNameIlídio
person.givenNameAndré Ferreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier1161643
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2315-CC5A-3DBB
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-7737-9288
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0604-2506
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56401521300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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