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Desenvolvimento de um sistema multiparticulado de alginato de cálcio para libertação prolongada de nanoemulsões
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| Documento em Acesso Embargado até dia 08-10-2028. Tente solicitar cópia ao autor carregando no ficheiro | 3.39 MB | Adobe PDF |
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O presente relatório foi elaborado no âmbito da Unidade Curricular de “Estágio” do Mestrado Integrado em Ciências Farmacêuticas da Universidade da Beira Interior. O documento está estruturado em três capítulos, cada um correspondente a uma das vertentes desenvolvidas: a componente de Investigação Científica (Capítulo I), a Experiência Profissionalizante em Farmácia Hospitalar (Capítulo II) e a Experiência Profissionalizante em Farmácia Comunitária (Capítulo III).
O primeiro capítulo é referente ao projeto de investigação intitulado por “Desenvolvimento de um sistema multiparticulado de alginato de cálcio para libertação prolongada de nanoemulsões”. Este trabalho foi desenvolvido no RISE-Health, da Universidade da Beira Interior, com o objetivo principal de formular nanoemulsões e proceder à sua encapsulação em partículas de alginato, com vista à melhoria da estabilidade e ao prolongamento da libertação de fármacos lipofílicos, nomeadamente a Nestorona®. As nanoemulsões foram encapsuladas em partículas de alginato, um polímero natural biocompatível e biodegradável, amplamente reconhecido pela sua capacidade de formar géis por reticulação iónica na presença de catiões divalentes, como o cálcio. A utilização deste sistema de libertação prolongada tem como finalidade reduzir a frequência de administração do fármaco, promovendo uma maior adesão ao regime terapêutico e, consequentemente, aumentando a eficácia do tratamento. No âmbito deste estudo, o corante Oil Red O, tradicionalmente utilizado para a coloração de lípidos em tecidos biológicos, foi empregado como marcador para monitorizar a libertação da nanoemulsão ao longo do tempo. Os resultados obtidos evidenciam o potencial das partículas de alginato contendo nanoemulsões como plataforma promissora para sistemas de libertação controlada de fármacos lipofílicos, particularmente em aplicações terapêuticas de longa duração.
O capítulo dois é dedicado ao estágio curricular desenvolvido na área de Farmácia Hospitalar, o qual decorreu entre os dias 3 de fevereiro e 28 de março de 2025, nos Serviços Farmacêuticos da Unidade Local de Saúde da Cova da Beira, sob a orientação da Dr.ª Maria Olímpia Fonseca. Este capítulo apresenta uma descrição detalhada das atividades realizadas durante o estágio, bem como dos diferentes setores de atuação do farmacêutico no contexto hospitalar.
O capítulo três aborda o estágio realizado em Farmácia Comunitária, que teve lugar entre 31 de março e 20 de junho de 2025, na Farmácia Pedroso, sob supervisão do Dr. João Vale. Neste capítulo, são descritas as diversas atividades inerentes à prática diária da farmácia comunitária, com ênfase nas funções e responsabilidades desempenhadas durante o período de estágio.
This report was prepared as part of the "Internship" course unit of the Integrated Master's Degree in Pharmaceutical Sciences at the University of Beira Interior. The document is structured into three chapters, each corresponding to one of the internship areas: the Scientific Research component (Chapter I), the Professional Experience in Hospital Pharmacy (Chapter II), and the Professional Experience in Community Pharmacy (Chapter III). Chapter One pertains to the research project entitled “Development of a multiparticulate calcium alginate system for sustained release of nanoemulsions”. This work was carried out at RISE-Health, University of Beira Interior, with the primary objective of formulating nanoemulsions and encapsulating them in alginate particles, aiming to enhance the stability and prolong the release of lipophilic drugs, namely Nestorone®. The nanoemulsions were encapsulated in alginate particles, a natural, biocompatible, and biodegradable polymer widely recognized for its ability to form gels through ionic crosslinking in the presence of divalent cations such as calcium. The application of this sustained-release system is intended to reduce the frequency of drug administration, thereby promoting greater adherence to the therapeutic regimen and, consequently, improving treatment efficacy. Within the scope of this study, the dye Oil Red O, traditionally used for staining lipids in biological tissues, was employed as a tracer to monitor the release of the nanoemulsion over time. The results obtained highlight the potential of alginate particles loaded with nanoemulsions as a promising platform for controlled-release systems of lipophilic drugs, particularly for long-term therapeutic applications. Chapter Two is dedicated to the curricular internship undertaken in the area of Hospital Pharmacy, which took place from February 3rd to March 28th, 2025, at the Pharmaceutical Services of the Local Health Unit of Cova da Beira, under the supervision of Drª Maria Olímpia Fonseca. This chapter provides a detailed description of the activities carried out during the internship, as well as of the various areas in which hospital pharmacists operate. Chapter Three addresses the internship carried out in Community Pharmacy, held from March 31st to June 20th, 2025, at Farmácia Pedroso, under the supervision of Dr João Vale. This chapter outlines the various activities inherent to the daily practice of community pharmacy, with particular emphasis on the roles and responsibilities assumed during the internship period.
This report was prepared as part of the "Internship" course unit of the Integrated Master's Degree in Pharmaceutical Sciences at the University of Beira Interior. The document is structured into three chapters, each corresponding to one of the internship areas: the Scientific Research component (Chapter I), the Professional Experience in Hospital Pharmacy (Chapter II), and the Professional Experience in Community Pharmacy (Chapter III). Chapter One pertains to the research project entitled “Development of a multiparticulate calcium alginate system for sustained release of nanoemulsions”. This work was carried out at RISE-Health, University of Beira Interior, with the primary objective of formulating nanoemulsions and encapsulating them in alginate particles, aiming to enhance the stability and prolong the release of lipophilic drugs, namely Nestorone®. The nanoemulsions were encapsulated in alginate particles, a natural, biocompatible, and biodegradable polymer widely recognized for its ability to form gels through ionic crosslinking in the presence of divalent cations such as calcium. The application of this sustained-release system is intended to reduce the frequency of drug administration, thereby promoting greater adherence to the therapeutic regimen and, consequently, improving treatment efficacy. Within the scope of this study, the dye Oil Red O, traditionally used for staining lipids in biological tissues, was employed as a tracer to monitor the release of the nanoemulsion over time. The results obtained highlight the potential of alginate particles loaded with nanoemulsions as a promising platform for controlled-release systems of lipophilic drugs, particularly for long-term therapeutic applications. Chapter Two is dedicated to the curricular internship undertaken in the area of Hospital Pharmacy, which took place from February 3rd to March 28th, 2025, at the Pharmaceutical Services of the Local Health Unit of Cova da Beira, under the supervision of Drª Maria Olímpia Fonseca. This chapter provides a detailed description of the activities carried out during the internship, as well as of the various areas in which hospital pharmacists operate. Chapter Three addresses the internship carried out in Community Pharmacy, held from March 31st to June 20th, 2025, at Farmácia Pedroso, under the supervision of Dr João Vale. This chapter outlines the various activities inherent to the daily practice of community pharmacy, with particular emphasis on the roles and responsibilities assumed during the internship period.
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Palavras-chave
Nanoemulsões Partículas de Alginato Libertação modificada Extrusão simples Farmácia Hospitalar Farmácia Comunitária Nanoemulsions Alginate Particles Modified Release Simple Extrusion Hospital Pharmacy Community Pharmacy