Publication
Emulsion Electrospun Fiber Mats of PCL/PVA/Chitosan and Eugenol for Wound Dressing Applications
| dc.contributor.author | Mouro, Cláudia | |
| dc.contributor.author | Simões, Manuel | |
| dc.contributor.author | Gouveia, Isabel C. | |
| dc.date.accessioned | 2019-11-04T10:49:54Z | |
| dc.date.available | 2019-11-04T10:49:54Z | |
| dc.date.issued | 2019-10-31 | |
| dc.description.abstract | In recent years, the damaging e ects of antimicrobial resistance relating to wound management and infections have driven the ongoing development of composite wound dressing mats containing natural compounds, such as plant extracts and their derivatives. e present research reports the fabrication of novel electrospun Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)/Chitosan (CS) ber mats loaded with Eugenol (EUG), an essential oil, known for its therapeutic properties. e electrospun ber mats were prepared via electrospinning from either water-in-oil (W/O) or oil-in-water (O/W) emulsions and characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), total porosity measurements, and water contact angle. e in vitro EUG release pro le and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were also evaluated. e obtained results proved that the EUG was loaded e ciently into electrospun PCL/PVA/CS ber mats and the two W/O and O/W emulsions prepared from the PCL/PVA/CS (7 : 3 : 1) and PCL/PVA/CS (3 : 7 : 1) revealed porosity within the ideal range of 60–90%, even when EUG was loaded. e measured contact angle values showed that the O/W emulsion exhibited a more hydrophilic character and the wettability noticeably decreased a¢er adding EUG in both emulsion blends. Furthermore, the electrospun PCL/PVA/CS ber mats demonstrated a rapid release of EUG during the rst 8 hours, which enhanced gradually a¢erward (up to 120 hours). Moreover, an e cient antibacterial activity against S. aureus (inhibition ratios of 92.43% and 83.08%) and P. aeruginosa (inhibition ratios of 94.68% and 87.85%) was displayed and the in vitro cytotoxic assay demonstrated that the normal human dermal broblasts (NHDF) remained viable for at least 7 days, a¢er direct contact with the produced electrospun ber mats. erefore, such ndings support the biocompatibility and suitability of using these EUG-loaded electrospun PCL/PVA/CS ber mats as a new innovative wound dressing material with potential for preventing and treating microbial wound infections. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1155/2019/9859506 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.6/7488 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.title | Emulsion Electrospun Fiber Mats of PCL/PVA/Chitosan and Eugenol for Wound Dressing Applications | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 11 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Advances in Polymer Technology | pt_PT |
| oaire.citation.volume | 2019 | pt_PT |
| person.familyName | Mouro | |
| person.familyName | Simões | |
| person.familyName | Gouveia | |
| person.givenName | Cláudia | |
| person.givenName | Manuel | |
| person.givenName | Isabel Cristina | |
| person.identifier | 626131 | |
| person.identifier.ciencia-id | 1617-CE39-FE0A | |
| person.identifier.ciencia-id | 5711-86D0-A54B | |
| person.identifier.orcid | 0000-0003-2148-9602 | |
| person.identifier.orcid | 0000-0002-3355-4398 | |
| person.identifier.orcid | 0000-0003-3290-9529 | |
| person.identifier.rid | K-1651-2014 | |
| person.identifier.scopus-author-id | 55608338000 | |
| person.identifier.scopus-author-id | 24328741500 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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