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Análise Metabólica Univariada de Biomarcadores Para a Doença de Parkinson em Idosos residentes em ERPI’s da Beira Interior
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Advisor(s)
Abstract(s)
Este relatório está organizado em dois capítulos, o primeiro referente ao trabalho realizado
para a vertente de investigação científica em Ciências Farmacêuticas, desenvolvido no Centro
de Investigação em Ciências da Saúde da Universidade da Beira Interior, sob a orientação do
Prof. Doutor Ignácio Verde e sob a co-orientação da Dra. Nádia Oliveira e o segundo referente
à experiência profissionalizante em farmácia comunitária.
O primeiro capítulo, intitulado “Análise Metabólica Univariada de Biomarcadores Para a
Doença de Parkinson em Idosos que Residem em ERPI’s da Beira Interior” descreve o trabalho
investigativo realizado na procura de novos biomarcadores para a doença de Parkinson. Como
descrito na literatura, a doença de Parkinson é a segunda doença neurodegenerativa mais
prevalente no mundo, com cerca de 1 % da população mundial a ser afetada pela mesma. As
principais dificuldades residem na dificuldade de diagnóstico, que é apenas clínico, isto
porque, a patofisiologia da doença é alvo de várias questões ainda por resolver. Assim, a
identificação de novos biomarcadores para a mesma é essencial, de forma a acelerar o
diagnóstico, bem como o tratamento e diminuir a progressão da doença. Neste trabalho foi
usada a Espetroscopia de Ressonância Magnética Nuclear para estudar alterações nos
metabolitos presentes na urina de idosos residentes em estruturas residenciais para idosos da
Beira Interior. Formaram-se dois grupos, um grupo controlo constituído por idosos sem a
doença de Parkinson e sem terapêutica para a mesma e outro grupo formado por idosos com a
doença de Parkinson ou a realizar terapêutica para a mesma, sem qualquer outra patologia
neurodegenerativa. Em nenhum dos grupos se inseriram indivíduos com diagnóstico de
doença oncológica, cardiovascular, endócrina, autoimune e renal (aguda ou crónica). A análise
estatística univariada mostrou diferenças significativas em cinco dos quarenta e quatro
metabolitos identificados, sendo que três se encontravam diminuídos e dois com
concentrações aumentadas. Estes metabolitos podem ser considerados como potenciais
biomarcadores para a doença de Parkinson.
O segundo capítulo descreve a minha experiência de estágio curricular em farmácia
comunitária na Farmácia Silveira de Mem Martins, em Mem Martins, Sintra, sob a supervisão
e orientação da Dra. Rita Nunes, no período de 9 de setembro de 2024 a 24 de janeiro de 2025.
Este estágio permitiu vivenciar o quotidiano de um farmacêutico comunitário e todos os
desafios que existem nesta área da profissão e aprender sobre as responsabilidades de gestão,
organização, dispensa e aconselhamento ao utente e a promoção do uso racional do medicamento. Este período foi o culminar desta fase de aprendizagem e contribuiu de forma
crucial para o meu desenvolvimento como futura farmacêutica.
This report is organized in two chapters: the first refers to the work conducted for the scientific research component in Pharmaceutical Sciences, developed at the Health Sciences Research Center of the University of Beira Interior, under the supervision of Prof. Dr. Ignácio Verde and co-supervision of Dr. Nádia Oliveira; the second relates to the professional training experience in community pharmacy. The first chapter, titled “Univariate Metabolic Analysis of Biomarkers for Parkinson’s Disease in Elderly Residents of Nursing Homes in Beira Interior”, describes the investigative work carried out in the search for new biomarkers for Parkinson’s disease. As described in the literature, Parkinson’s disease is the second most prevalent neurodegenerative disease globally, affecting approximately 1% of the world’s population. The primary challenges lie in the difficulty of diagnosis, which is solely clinical, as the pathophysiology of the disease raises several unresolved questions. Thus, the identification of new biomarkers is crucial to accelerate diagnosis, improve treatment, and reduce disease progression. In this study, Nuclear Magnetic Resonance Spectroscopy was used to investigate changes in metabolites present in the urine of elderly residents nursery homes in the Beira Interior region. Two groups were formed: a control group consisting of elderly individuals without Parkinson’s disease and not undergoing of any treatment for it, and another group composed of elderly individuals with Parkinson’s disease or undergoing treatment for it, without any other neurodegenerative conditions. Neither of the two groups included individuals with diagnosed oncological, cardiovascular, endocrine, autoimmune, or renal diseases (acute or chronic). Univariate statistical analysis revealed significant differences in five of the forty-four identified metabolites, with three showing decreased concentrations and two showing increased concentrations. These metabolites may be considered potential biomarkers for Parkinson’s disease. The second chapter describes my curricular internship experience in community pharmacy at Farmácia Silveira de Mem Martins, in Mem Martins, Sintra, under the supervision and guidance of Dr. Rita Nunes, from September 9, 2024, to January 24, 2025. This internship provided an opportunity to experience the daily life of a community pharmacist and the challenges associated with this area of the profession. I learned about responsibilities in management, organization, dispensing medicines and advising patients, and promoting the rational use of medicines. This period marked the culmination of this phase of my education and contributed significantly to my development as a future pharmacist.
This report is organized in two chapters: the first refers to the work conducted for the scientific research component in Pharmaceutical Sciences, developed at the Health Sciences Research Center of the University of Beira Interior, under the supervision of Prof. Dr. Ignácio Verde and co-supervision of Dr. Nádia Oliveira; the second relates to the professional training experience in community pharmacy. The first chapter, titled “Univariate Metabolic Analysis of Biomarkers for Parkinson’s Disease in Elderly Residents of Nursing Homes in Beira Interior”, describes the investigative work carried out in the search for new biomarkers for Parkinson’s disease. As described in the literature, Parkinson’s disease is the second most prevalent neurodegenerative disease globally, affecting approximately 1% of the world’s population. The primary challenges lie in the difficulty of diagnosis, which is solely clinical, as the pathophysiology of the disease raises several unresolved questions. Thus, the identification of new biomarkers is crucial to accelerate diagnosis, improve treatment, and reduce disease progression. In this study, Nuclear Magnetic Resonance Spectroscopy was used to investigate changes in metabolites present in the urine of elderly residents nursery homes in the Beira Interior region. Two groups were formed: a control group consisting of elderly individuals without Parkinson’s disease and not undergoing of any treatment for it, and another group composed of elderly individuals with Parkinson’s disease or undergoing treatment for it, without any other neurodegenerative conditions. Neither of the two groups included individuals with diagnosed oncological, cardiovascular, endocrine, autoimmune, or renal diseases (acute or chronic). Univariate statistical analysis revealed significant differences in five of the forty-four identified metabolites, with three showing decreased concentrations and two showing increased concentrations. These metabolites may be considered potential biomarkers for Parkinson’s disease. The second chapter describes my curricular internship experience in community pharmacy at Farmácia Silveira de Mem Martins, in Mem Martins, Sintra, under the supervision and guidance of Dr. Rita Nunes, from September 9, 2024, to January 24, 2025. This internship provided an opportunity to experience the daily life of a community pharmacist and the challenges associated with this area of the profession. I learned about responsibilities in management, organization, dispensing medicines and advising patients, and promoting the rational use of medicines. This period marked the culmination of this phase of my education and contributed significantly to my development as a future pharmacist.
Description
Keywords
Biomarcadores Doença de Parkinson Farmácia Comunitária Idosos Institucionalizados Rmn