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Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT

2023-01-14Journal article Open access
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dc.contributor.authorNave, Micaela
dc.contributor.authorCosta, Francisco J. P.
dc.contributor.authorAlves, Cátia
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorDiogo, Duarte de Melo
dc.date.accessioned2023-04-04T11:25:42Z
dc.date.embargo2025-04-04
dc.date.issued2023-01-14
dc.description.abstractNear infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomaterials for cancer chemophotodynamic/photothermal therapy is a complex process. First, nanomaterials with photothermal capacity are synthesized, being then loaded with photosensitizers plus chemotherapeutics, and, finally functionalized with polymers for achieving suitable biological properties. To overcome this limitation, in this work, a novel straightforward approach to attain NIR light-responsive nanosystems for cancer chemo-photodynamic/ photothermal therapy was established. Such was accomplished by synthesizing poly(2-ethyl-2-oxazoline)- IR780 amphiphilic conjugates, which can be assembled into nanoparticles with photodynamic/photothermal capabilities that simultaneously encapsulate Doxorubicin (DOX/PEtOx-IR NPs). The DOX/PEtOx-IR NPs presented a suitable size and surface charge for cancer-related applications. When irradiated with NIR light, the DOX/PEtOx-IR NPs produced singlet oxygen as well as a smaller thermic effect that boosted the release of DOX by 1.7-times. In the in vitro studies, the combination of DOX/PEtOx-IR NPs and NIR light could completely ablate breast cancer cells (viability ≈ 4 %), demonstrating the enhanced outcome arising from the nanomaterials' chemo-photodynamic/photothermal therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejpb.2023.01.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13290
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCombinatorial triple therapypt_PT
dc.subjectLight responsive nanoparticlespt_PT
dc.subjectMultifunctional nanomaterialspt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectPoly(2-ethyl-2-oxazoline)pt_PT
dc.subjectPolymer-IR780 conjugatept_PT
dc.titleSimple preparation of POxylated nanomaterials for cancer chemo-PDT/PTTpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.citation.endPage15pt_PT
oaire.citation.startPage7pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume184pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC IND4ed
person.familyNameNave
person.familyNamePalácio Costa
person.familyNameAlves
person.familyNameSousa
person.familyNameLopes Melo
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameMicaela
person.givenNameFrancisco José
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNameBruna Daniela
person.givenNameIlídio
person.givenNameDuarte
person.identifierUMbJ1KMAAAAJ
person.identifierC2z5x04AAAAJ
person.identifier.ciencia-id4012-E7C6-84BA
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id5717-CB52-B4E5
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.orcid0000-0002-7834-2532
person.identifier.orcid0000-0003-2703-7738
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editora.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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