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Advisor(s)
Abstract(s)
Near infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting
several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic
therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and
trigger the release of drugs from the nanomaterials’ core. However, engineering nanomaterials for cancer chemophotodynamic/photothermal therapy is a complex process. First, nanomaterials with photothermal capacity are
synthesized, being then loaded with photosensitizers plus chemotherapeutics, and, finally functionalized with
polymers for achieving suitable biological properties. To overcome this limitation, in this work, a novel
straightforward approach to attain NIR light-responsive nanosystems for cancer chemo-photodynamic/
photothermal therapy was established. Such was accomplished by synthesizing poly(2-ethyl-2-oxazoline)-
IR780 amphiphilic conjugates, which can be assembled into nanoparticles with photodynamic/photothermal
capabilities that simultaneously encapsulate Doxorubicin (DOX/PEtOx-IR NPs). The DOX/PEtOx-IR NPs presented a suitable size and surface charge for cancer-related applications. When irradiated with NIR light, the
DOX/PEtOx-IR NPs produced singlet oxygen as well as a smaller thermic effect that boosted the release of DOX
by 1.7-times. In the in vitro studies, the combination of DOX/PEtOx-IR NPs and NIR light could completely ablate breast cancer cells (viability ≈ 4 %), demonstrating the enhanced outcome arising from the nanomaterials' chemo-photodynamic/photothermal therapy.
Description
Keywords
Combinatorial triple therapy Light responsive nanoparticles Multifunctional nanomaterials Photodynamic therapy Poly(2-ethyl-2-oxazoline) Polymer-IR780 conjugate
Citation
Publisher
Elsevier