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UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

2019-03-19Journal article Open access
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dc.contributor.authorLorigo, Margarida
dc.contributor.authorAntunes, Carla
dc.contributor.authorLemos, Manuel C.
dc.contributor.authorOliveira, J. Martinez de
dc.contributor.authorGranadeiro, Luiza Breitenfeld
dc.contributor.authorCairrão, Elisa
dc.date.accessioned2020-03-02T11:01:14Z
dc.date.available2020-03-02T11:01:14Z
dc.date.issued2019-03-19
dc.description.abstractUltraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world's most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms20061376pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9649
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre for Environmental and Marine Studies
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCalcium Channel Blockerspt_PT
dc.subjectCinnamatespt_PT
dc.subjectCyclic GMPpt_PT
dc.subjectEnzyme Activationpt_PT
dc.subjectHumanspt_PT
dc.subjectModels, Biologicalpt_PT
dc.subjectMyocytes Smooth Musclept_PT
dc.subjectSoluble Guanylyl Cyclasept_PT
dc.subjectUmbilical Arteriespt_PT
dc.subjectVasoconstrictionpt_PT
dc.subjectVasodilationpt_PT
dc.subjectUltraviolet Rayspt_PT
dc.titleUV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAMB%2F50017%2F2019/PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1376pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLorigo
person.familyNameQuintaneiro Antunes
person.familyNameLemos
person.familyNameMartinez Souto de Oliveira
person.familyNameGranadeiro
person.familyNameCairrao Rodrigues Oliveira
person.givenNameMargarida
person.givenNameCarla Patrícia
person.givenNameManuel
person.givenNameJosé António
person.givenNameLuiza Breitenfeld
person.givenNameMaria Elisa
person.identifierA-8367-2008
person.identifier274116
person.identifierAAB-1164-2020
person.identifier.ciencia-id9517-3DD1-8A12
person.identifier.ciencia-id4C1A-8436-8E3D
person.identifier.ciencia-id4B16-606C-8760
person.identifier.ciencia-id8812-C62C-364F
person.identifier.ciencia-idE71F-B2E5-D657
person.identifier.ciencia-id0611-71B8-191E
person.identifier.orcid0000-0002-4752-6398
person.identifier.orcid0000-0002-1151-8177
person.identifier.orcid0000-0001-9326-8900
person.identifier.orcid0000-0001-8608-0248
person.identifier.orcid0000-0001-8550-1645
person.identifier.orcid0000-0002-4823-5701
person.identifier.ridD-9861-2013
person.identifier.ridP-1852-2015
person.identifier.scopus-author-id8876185600
person.identifier.scopus-author-id35496279500
person.identifier.scopus-author-id34467456600
person.identifier.scopus-author-idScopus Author ID: 23476537500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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