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Advisor(s)
Abstract(s)
A presente dissertação encontra-se inserida na Unidade Curricular “Estágio”, do
Mestrado Integrado em Ciências Farmacêuticas. Este trabalho encontra-se dividido em
3 capítulos, que descrevem, respetivamente, a minha experiência profissionalizante na
vertente de investigação, farmácia hospitalar e farmácia comunitária.
O primeiro capítulo intitula-se “Origanum vulgare L.: composição química,
bioatividades e usos terapêuticos” e foi realizado no âmbito da componente de
investigação, sob orientação da Prof.ª Doutora Branca Maria Cardoso Monteiro da
Silva. Atualmente, a fitoterapia assume particular destaque, uma vez que a sociedade
procura alternativas naturais e com menos efeitos secundários para o tratamento de
inúmeras doenças. O presente trabalho de investigação teve como objetivo estudar a
composição química, bioatividades e usos terapêuticos da espécie Origanum vulgare.
Os métodos deste trabalho consistiram na pesquisa bibliográfica de informação técnica
e científica sobre esta espécie botânica, recorrendo para isso a diversas bases de dados.
Os autores são unânimes em considerar que os compostos presentes no óleo essencial,
nomeadamente timol e carvacrol, e os compostos fenólicos, em particular ácido
rosmarínico, ácido cafeico, ácido p-cumárico, ácido protocatecuico e quercetina, são os
principais princípios ativos responsáveis pelos efeitos terapêuticos. A revisão da
literatura permitiu concluir que Origanum vulgare é uma fonte altamente valiosa de
compostos com importantes efeitos biológicos, assumindo particular destaque a
atividade antioxidante e antimicrobiana. Estes resultados poderão abrir novas direções
de pesquisa para projetar novos medicamentos de elevada importância terapêutica,
recorrendo a plantas.
O segundo capítulo é relativo ao estágio curricular em farmácia hospitalar,
desenvolvido no período compreendido entre 8 de setembro a 30 de outubro de 2020
nos Serviços Farmacêuticos do Centro Hospitalar Universitário Cova da Beira, sob
orientação da Dra. Olímpia Fonseca. Este capítulo pretende descrever o
funcionamento, organização e principais áreas de atuação farmacêutica nos diversos
setores da farmácia hospitalar. Este estágio permitiu-me integrar uma equipa
multidisciplinar e contactar com uma das realidades da profissão farmacêutica.
O terceiro capítulo retrata a minha experiência durante o período de estágio curricular
em farmácia comunitária. Este estágio foi desenvolvido na Farmácia Pedroso, localizada na cidade da Covilhã, e decorreu de 2 de novembro de 2020 a 22 de janeiro
de 2021, sob orientação do Dr. João Vale. Nesta componente são descritas as atividades
desempenhadas diariamente num contexto de farmácia comunitária, bem como o
enquadramento ético, legal e financeiro, permitindo-me compreender de forma clara e
profícua a importância do papel do farmacêutico comunitário em contexto real.
This dissertation is inserted in the Curricular Unit “Internship”, of the Integrated Master in Pharmaceutical Sciences. This work is divided into 3 chapters, which describe, respectively, my professional experience in research, hospital pharmacy and community pharmacy. The first chapter is entitled “Origanum vulgare L.: chemical composition, bioactivities and therapeutic uses” and was carried out within the scope of the research component, under the supervision of Prof. Dr. Branca Maria Cardoso Monteiro da Silva. Currently, phytotherapy is particularly important as society seeks natural alternatives with fewer side effects for the treatment of numerous diseases. This research work aimed to study the chemical composition, bioactivities and therapeutic uses of Origanum vulgare. The research methodology consisted of a bibliographic search of technical and scientific information about this botanical specie, using different databases. The authors are unanimous in considering that compounds present in essential oil, namely thymol and carvacrol, and phenolic compounds, in particular rosmarinic acid, caffeic acid, pcumaric acid, protocatechuic acid and quercetin, prove to be the main active ingredients responsible for the therapeutic effects. The literature review concluded that Origanum vulgare is a highly valuable source of compounds with important biological effects, in particular the antioxidant and antimicrobial activities. These results may open new directions for research to design new drugs of high therapeutic relevance, using plants. The second chapter refers to the internship in hospital pharmacy, developed in the period between September 8, 2020 to October 30, 2020 at the Pharmaceutical Services of the Cova da Beira Universitary Hospitalar Center, under the guidance of Dr. Olímpia Fonseca. This chapter describes the operation, organization and main areas of pharmaceutical activity in the different sectors of hospital pharmacy. This internship allowed me to be part of a multidisciplinary team and contact with one of the realities of the hospital pharmaceutical profession. The third chapter portrays my experience during the internship period in community pharmacy. This internship was developed at Pedroso pharmacy, located in the city of Covilhã, and took place from November 2, 2020 to January 22, 2021, under the guidance of Dr. João Vale. This component describes the activities performed daily in a community pharmacy context, as well as the ethical, legal and financial framework, allowing me to understand the importance of the community pharmacist in a real context.
This dissertation is inserted in the Curricular Unit “Internship”, of the Integrated Master in Pharmaceutical Sciences. This work is divided into 3 chapters, which describe, respectively, my professional experience in research, hospital pharmacy and community pharmacy. The first chapter is entitled “Origanum vulgare L.: chemical composition, bioactivities and therapeutic uses” and was carried out within the scope of the research component, under the supervision of Prof. Dr. Branca Maria Cardoso Monteiro da Silva. Currently, phytotherapy is particularly important as society seeks natural alternatives with fewer side effects for the treatment of numerous diseases. This research work aimed to study the chemical composition, bioactivities and therapeutic uses of Origanum vulgare. The research methodology consisted of a bibliographic search of technical and scientific information about this botanical specie, using different databases. The authors are unanimous in considering that compounds present in essential oil, namely thymol and carvacrol, and phenolic compounds, in particular rosmarinic acid, caffeic acid, pcumaric acid, protocatechuic acid and quercetin, prove to be the main active ingredients responsible for the therapeutic effects. The literature review concluded that Origanum vulgare is a highly valuable source of compounds with important biological effects, in particular the antioxidant and antimicrobial activities. These results may open new directions for research to design new drugs of high therapeutic relevance, using plants. The second chapter refers to the internship in hospital pharmacy, developed in the period between September 8, 2020 to October 30, 2020 at the Pharmaceutical Services of the Cova da Beira Universitary Hospitalar Center, under the guidance of Dr. Olímpia Fonseca. This chapter describes the operation, organization and main areas of pharmaceutical activity in the different sectors of hospital pharmacy. This internship allowed me to be part of a multidisciplinary team and contact with one of the realities of the hospital pharmaceutical profession. The third chapter portrays my experience during the internship period in community pharmacy. This internship was developed at Pedroso pharmacy, located in the city of Covilhã, and took place from November 2, 2020 to January 22, 2021, under the guidance of Dr. João Vale. This component describes the activities performed daily in a community pharmacy context, as well as the ethical, legal and financial framework, allowing me to understand the importance of the community pharmacist in a real context.
Description
Keywords
Ácidos Fenólicos Antimicrobiano Antioxidante Farmácia Comunitária Farmácia Hospitalar Flavonóides Óleo Essencial Orégão Origanum Vulgare L.