| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 4.72 MB | Adobe PDF |
Authors
Abstract(s)
A presente dissertação, inserida na unidade curricular “Estágio” do Mestrado Integrado em Ciências Farmacêuticas, encontra-se dividida em três capítulos: componente de Investigação Laboratorial, estágio em Farmácia Hospitalar e estágio em Farmácia Comunitária.
O primeiro capítulo é alusivo à componente de Investigação Laboratorial, desenvolvida no Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior (CICS-UBI). Os produtos semi-sólidos de aplicação vaginal são muito usados pelas mulheres, principalmente para tratar infeções vaginais, assim como sintomas decorrentes da menopausa. O principal objetivo deste trabalho consistiu em desenvolver e melhorar os métodos de caracterização tradicionais das formulações semi-sólidas de aplicação vaginal, utilizando parâmetros fisiológicos e patológicos, de modo a prever com maior precisão o comportamento in vivo nas fases iniciais de desenvolvimento. Foram estudadas dez formulações semi-sólidas vaginais terapêuticas comercializadas no mercado Português e Internacional (Dalacin V®, Dermofix®, Gino-Canesten®, Gino Travogen®, Gyno-Pevaryl®, Lomexin®, Sertopic®, Blissel®, Colpotrophine® e Ovestin®). Além disso, foram incluídos dois produtos controlo: Placebo Universal e Replens®. Para estudar as principais características tecnológicas dos diferentes produtos teve-se em conta a temperatura corporal e a diluição que ocorre após contacto com o fluido vaginal após a administração vaginal, na situação clínica particular para os quais são utilizados. Os produtos foram caracterizados em termos de: parâmetros texturométricos após diluição fisiológica em simulante de fluido vaginal (SFV) e simulante de fluido vaginal modificado com mucina (SFVm), à temperatura ambiente (25ºC) e à temperatura corporal (37ºC) e, após diluição patológica com SFV a 37ºC; osmolalidade e viscosidade após diluições patológicas em SFV a 37ºC. As emulsões em estudo foram ainda classificadas como água-em-óleo (A/O) ou óleo-em-água (O/A), antes e após diluição nos mesmos simulantes. O presente estudo e avaliação destas formulações vieram ressalvar que as condições experimentais podem influenciar significativamente os parâmetros tecnológicos devendo, por isso, ser adequadas ao objetivo do estudo. Concluiu-se, assim, que as adaptações metodológicas propostas permitem otimizar a caracterização in vitro de semi-sólidos vaginais, no desenvolvimento e estudo de novas formulações, contribuindo para otimização de tempo e recursos no processo de desenvolvimento de produtos mais adequados à utilização clínica vaginal.
O segundo capítulo refere-se à componente de estágio no âmbito de Farmácia Hospitalar. Este realizou-se no Hospital Nossa Senhora da Assunção, em Seia, e no Hospital Sousa Martins, na Guarda. A oportunidade de vivenciar esta experiência em dois hospitais permitiu-me contactar com duas realidades do Serviço Nacional de Saúde e integrar em duas equipas de trabalho diferentes. Neste estágio, aprendi e desenvolvi várias competências para o bom funcionamento dos serviços farmacêuticos, uma vez que estes constituem uma estrutura fulcral nos cuidados de saúde prestados em meio hospitalar, como: a gestão (seleção, aquisição, aprovisionamento, armazenamento e distribuição) dos medicamentos e produtos de saúde; produção e controlo de medicamentos; participação nas Comissões Técnicas; e aprendizagem do papel do farmacêutico nas áreas de Farmácia Clínica, Farmacocinética, Farmacovigilância e na prestação de outros cuidados farmacêuticos.
O terceiro capítulo aborda a componente de estágio em Farmácia Comunitária, realizado na Farmácia Coelho, na cidade de Seia. Este permitiu-me integrar numa equipa de trabalho diversificada e competente, com a atenção centralizada no utente, na sua saúde, bem-estar e, principalmente no seu acompanhamento farmacoterapêutico. No seguimento das tarefas realizadas na farmácia, tive a oportunidade de experienciar e adquirir as principais competências como: gestão farmacêutica, aquisição dos diferentes medicamentos e produtos de saúde; estudo, planificação, geração, receção e conferência de encomendas; regras de armazenamento; interação farmacêutico-utente-medicamento no atendimento ao público e no aconselhamento especializado e individualizado; promoção do uso racional dos medicamentos; prestação de outros cuidados de saúde como a medição e avaliação de parâmetros biológicos e, preparação e distribuição de medicação; e por fim, receituário e faturação.
The present dissertation, included in the curricular unit "Internship" of the Integrated Master’s Degree in Pharmaceutical Sciences, is divided into three chapters, concerning firstly, a laboratorial research component, and then, the reports about the Hospital Pharmacy and Community Pharmacy internships. The first chapter refers to the component of Laboratorial Research, developed at the Health Sciences Investigation Center of University of Beira Interior (CICS-UBI). Semi-solid products of vaginal application are widely used by women, mainly to treat vaginal infections, as well as symptoms arising from menopause. The main objective of this work was to develop and improve the traditional characterization methods of semi-solid formulations of vaginal application, using physiological and pathological parameters, in order to predict more accurately the in vivo behavior in the early stages of development. Ten vaginal semi-solid formulations marketed in the Portuguese and representative of the International market were studied (Dalacin V®, Dermofix®, Gino-Canesten®, Gino Travogen®, Gyno-Pevaryl®, Lomexin®, Sertopic®, Blissel®, Colpotrophine® e Ovestin®). In addition, two control products were included: Placebo Universal and Replens®. The main technological characteristics of these products were studied, taking into account the body temperature and the dilution occurring after contact with the vaginal fluid after vaginal administration. Also, the particular clinical situation for which they are used was mimetized. The products were characterized in terms of: texturometric parameters after physiological dilution in vaginal fluid simulant (VFS) and modified vaginal fluid simulant containing mucin (VFSm), at room temperature (25ºC) and at body temperature (37ºC) and, after diluting in the pH and volume conditions specific of each pathology with VFS at 37ºC; osmolality and viscosity after dilutions in a pathological featuring in VFS at 37ºC. The emulsions in study were also classified as water-in-oil (W/O) or oil-in-water (O/W), before and after dilution in the same simulants. The present study and evaluation of these formulations have reinforced that the experimental conditions can influence significantly the technological parameters and should, therefore, be adequate to the objective of the study. It was concluded that the proposed methodological adaptations allow the optimization of the in vitro characterization of vaginal semi-solids in the early steps of development and study of new formulations. These adaptations can contribute to the optimization of time and resources in the process of developing products more suitable for clinical vaginal use. The second chapter refers to the internship component within the scope of Hospital Pharmacy. This was held at the Hospital Nossa Senhora da Assunção, in Seia, and at the Hospital Sousa Martins, in Guarda. The opportunity to experience the workflow of two different hospitals allowed me to contact with two realities of the National Health Service and integrate into two different work teams. At this internship, I have learned and developed several competencies for the proper functioning of pharmaceutical services within the hospital context, since they constitute a central structure in healthcare provided in a hospital environment, such as: management (selection, acquisition, storage and distribution) of medicines and health products; production and control of medicines; participation in the Technical Commissions; and deepening the role of the pharmacist in the areas of Clinical Pharmacy, Pharmacokinetics, Pharmacovigilance and the provision of other pharmaceutical care. The third chapter addresses the internship component in Community Pharmacy, held at the Coelho Pharmacy, in the city of Seia. This allowed me to endorse a team of diversified and competent work, with a special focus on the patients, their health, welfare and, mainly, their pharmacotherapeutic monitoring. Concerning the tasks performed at the pharmacy, I had the opportunity to experience and acquire main competences, such as: pharmaceutical management, acquisition of different medicines and health products; study, planning, generation, reception and conference of orders; storage rules; pharmacist-patient-medicine interaction in the public service and specialized and individualized counseling; promoting the rational use of medicines; provision of other health care services, like such as measurement and evaluation of biological parameters and preparation and distribution of medication; and finally, prescription and billing.
The present dissertation, included in the curricular unit "Internship" of the Integrated Master’s Degree in Pharmaceutical Sciences, is divided into three chapters, concerning firstly, a laboratorial research component, and then, the reports about the Hospital Pharmacy and Community Pharmacy internships. The first chapter refers to the component of Laboratorial Research, developed at the Health Sciences Investigation Center of University of Beira Interior (CICS-UBI). Semi-solid products of vaginal application are widely used by women, mainly to treat vaginal infections, as well as symptoms arising from menopause. The main objective of this work was to develop and improve the traditional characterization methods of semi-solid formulations of vaginal application, using physiological and pathological parameters, in order to predict more accurately the in vivo behavior in the early stages of development. Ten vaginal semi-solid formulations marketed in the Portuguese and representative of the International market were studied (Dalacin V®, Dermofix®, Gino-Canesten®, Gino Travogen®, Gyno-Pevaryl®, Lomexin®, Sertopic®, Blissel®, Colpotrophine® e Ovestin®). In addition, two control products were included: Placebo Universal and Replens®. The main technological characteristics of these products were studied, taking into account the body temperature and the dilution occurring after contact with the vaginal fluid after vaginal administration. Also, the particular clinical situation for which they are used was mimetized. The products were characterized in terms of: texturometric parameters after physiological dilution in vaginal fluid simulant (VFS) and modified vaginal fluid simulant containing mucin (VFSm), at room temperature (25ºC) and at body temperature (37ºC) and, after diluting in the pH and volume conditions specific of each pathology with VFS at 37ºC; osmolality and viscosity after dilutions in a pathological featuring in VFS at 37ºC. The emulsions in study were also classified as water-in-oil (W/O) or oil-in-water (O/W), before and after dilution in the same simulants. The present study and evaluation of these formulations have reinforced that the experimental conditions can influence significantly the technological parameters and should, therefore, be adequate to the objective of the study. It was concluded that the proposed methodological adaptations allow the optimization of the in vitro characterization of vaginal semi-solids in the early steps of development and study of new formulations. These adaptations can contribute to the optimization of time and resources in the process of developing products more suitable for clinical vaginal use. The second chapter refers to the internship component within the scope of Hospital Pharmacy. This was held at the Hospital Nossa Senhora da Assunção, in Seia, and at the Hospital Sousa Martins, in Guarda. The opportunity to experience the workflow of two different hospitals allowed me to contact with two realities of the National Health Service and integrate into two different work teams. At this internship, I have learned and developed several competencies for the proper functioning of pharmaceutical services within the hospital context, since they constitute a central structure in healthcare provided in a hospital environment, such as: management (selection, acquisition, storage and distribution) of medicines and health products; production and control of medicines; participation in the Technical Commissions; and deepening the role of the pharmacist in the areas of Clinical Pharmacy, Pharmacokinetics, Pharmacovigilance and the provision of other pharmaceutical care. The third chapter addresses the internship component in Community Pharmacy, held at the Coelho Pharmacy, in the city of Seia. This allowed me to endorse a team of diversified and competent work, with a special focus on the patients, their health, welfare and, mainly, their pharmacotherapeutic monitoring. Concerning the tasks performed at the pharmacy, I had the opportunity to experience and acquire main competences, such as: pharmaceutical management, acquisition of different medicines and health products; study, planning, generation, reception and conference of orders; storage rules; pharmacist-patient-medicine interaction in the public service and specialized and individualized counseling; promoting the rational use of medicines; provision of other health care services, like such as measurement and evaluation of biological parameters and preparation and distribution of medication; and finally, prescription and billing.
Description
Keywords
Administração Vaginal Caracterização Tecnológica Adaptada Farmacêutico Farmácia Comunitária. Farmácia Hospitalar Formulações Semi-Sólidas Vaginais In Vitro Produtos Vaginais Simulantes de Fluido Vaginal