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Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes

2009Journal article Open access
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dc.contributor.authorCosta, Aldo M.
dc.contributor.authorSilva, António
dc.contributor.authorGarrido, Nuno
dc.contributor.authorLouro, Hugo
dc.contributor.authorMarinho, Daniel
dc.contributor.authorMarques, MC
dc.contributor.authorGranadeiro, Luiza Breitenfeld
dc.date.accessioned2020-02-28T11:12:27Z
dc.date.available2020-02-28T11:12:27Z
dc.date.issued2009
dc.description.abstractPrevious studies have associated angiotensin-converting enzyme (ACE) D allele with variability in the skeletal muscle baseline strength, though conclusions have been inconsistent across investigations. The purpose of this study was to examine the possible association between ACE genotype and skeletal muscle baseline strength in elite male and female athletes involved in different event expertise. A group of 58 elite athletes, designated as Olympic candidates, were studied: 35 swimmers (19 males and 16 females, 18.8 ± 3.2 years) and 23 triathletes (15 males and 8 females, 18.7 ± 3.0 years). The athletes were classified as: short (≤ 200m) and middle (400m to 1500m) distance athletes, respectively. For each subject the grip strength in both hands was measure using an adjustable mechanical hand dynamometer. The maximum height in both squat jump (SJ) and counter movement jump (CMJ) were also assessed, using a trigonometric carpet (Ergojump Digitime 1000; Digitest, Jyvaskyla, Finland). DNA extraction was obtained with Chelex 100(®) and genotype determination by PCR-RFLP methods. Both males and females showed significantly higher right grip strength in D allele carriers compared to II homozygote's. We found that allelic frequency differs significantly by event distance specialization in both genders (p < 0.05). In fact, sprinter D allele carriers showed the superior scores in nearly all strength measurements (p < 0.05), in both genders. Among endurance athletes, the results also demonstrated that female D allele carriers exhibited the higher performance right grip and CMJ scores (p < 0.05). In conclusion, the ACE D allele seems associated with skeletal muscle baseline strength in elite athletes, being easily identified in females. Key pointsDD homozygote's and D allele carriers from both genders shows significantly higher right grip strength.Right grip strength remains significantly higher in the D allele carrier's female endurance group.Female's D allele carriers exhibited the higher performance counter-movement jump scores.ACE genotype effects in skeletal-muscle strength are diverse by gender, being easily identified in females.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9620
dc.language.isoengpt_PT
dc.relationESTUDO DE PARÂMETROS GENÉTICOS QUE INFLUENCIAM O RENDIMENTO DESPORTIVO EM NADADORES DE ALTA COMPETIÇÃO
dc.subjectSwimmingpt_PT
dc.subjectGenetic polymorphismpt_PT
dc.subjectSport performancept_PT
dc.subjectTriathlonpt_PT
dc.titleAngiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleESTUDO DE PARÂMETROS GENÉTICOS QUE INFLUENCIAM O RENDIMENTO DESPORTIVO EM NADADORES DE ALTA COMPETIÇÃO
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F40243%2F2007/PT
oaire.citation.endPage418pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage410pt_PT
oaire.citation.titleJournal of Sports Science and Medicinept_PT
oaire.citation.volume8pt_PT
person.familyNameM. Costa
person.familyNameSilva
person.familyNameGarrido
person.familyNameLouro
person.familyNameMarinho
person.familyNameMARQUES
person.familyNameGranadeiro
person.givenNameAldo
person.givenNameAntónio
person.givenNameNuno Miguel de Figueiredo
person.givenNameHugo
person.givenNameDaniel
person.givenNameMÁRIO
person.givenNameLuiza Breitenfeld
person.identifier896755
person.identifierhttps://scholar.google.com/citations?user=0B3tQQcAAAAJ&amp;hl=en&amp;authuser=2
person.identifier274116
person.identifier.ciencia-id0A15-F655-DDDE
person.identifier.ciencia-id8C15-83CB-5566
person.identifier.ciencia-id3711-341B-A441
person.identifier.ciencia-id8019-E11F-9609
person.identifier.ciencia-id471B-F3CC-479A
person.identifier.ciencia-idEA13-7532-0A6D
person.identifier.ciencia-idE71F-B2E5-D657
person.identifier.orcid0000-0003-0296-9707
person.identifier.orcid0000-0001-5790-5116
person.identifier.orcid0000-0001-7404-6923
person.identifier.orcid0000-0001-5635-2476
person.identifier.orcid0000-0003-2351-3047
person.identifier.orcid0000-0002-5812-1580
person.identifier.orcid0000-0001-8550-1645
person.identifier.ridP-1852-2015
person.identifier.scopus-author-id35518382800
person.identifier.scopus-author-id13410238400
person.identifier.scopus-author-idhttps://www.scopus.com/authid/detail.uri?authorId=53866322700
person.identifier.scopus-author-id15022568500
person.identifier.scopus-author-id24773599000
person.identifier.scopus-author-id34467456600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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