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Advisor(s)
Abstract(s)
Sensitive skin diseases, including atopic dermatitis, skin inflammation and bedsores,
leave patients vulnerable under hospital setting. It is important for the development
of a hospital gown with ‘‘soft hand’’ properties and at the same time as a protector
against nosocomial infections. Klebsiella pneumoniae has developed resistance to
antibiotics in the carbapenem antibiotic class, known as carbapenem-resistant
K. pneumoniae (CRKP). CRKP is resistant to nearly all antibiotics and can kill up to
50% of infected patients.
This work consisted in the development of a washable recycled silk fibroin-based
gown covalently linked with an amino acid L-Cysteine(L-Cys), focused on prevention of
K. pneumoniae establishment, proliferation and spreading to community, for use under
hospital settings. With the growing problem of resistance to antibiotics and few new
therapies on the horizon, gowns adsorbed with L-Cys show to function as a barrier to
the establishment and proliferation of microorganisms, providing user protection from
infectious disease. This gown was knitted at a rectilinear needle loom with a Jersey knit structure. Then it was cross-linked with L-Cys, subjected to laundry, and subsequently
characterized by energy-dispersive X-ray spectroscopy, Fourier transform infrared
spectroscopy, contact angle, free energy of adhesion, scanning electron microscopy
and transmission electron microscopy. Results presented a bactericidal effect against
K. pneumoniae of 94.92% after three rinses and 88.88% after five washing cycles, with the
few adhered bacteria with an altered and compromised morphology.
Description
Keywords
L-Cysteine Antimicrobial-gown Nosocomial infections Aminolysis Klebsiella pneumoniae