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New garment proposal for prevention of spreading Gram-negative bacteria resistant to carbapenem antibiotic class under hospital settings

2016Journal article Open access
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dc.contributor.authorNogueira, Frederico
dc.contributor.authorGomes, Ana
dc.contributor.authorGouveia, Isabel C.
dc.date.accessioned2019-11-04T11:13:58Z
dc.date.available2019-11-04T11:13:58Z
dc.date.issued2016
dc.description.abstractSensitive skin diseases, including atopic dermatitis, skin inflammation and bedsores, leave patients vulnerable under hospital setting. It is important for the development of a hospital gown with ‘‘soft hand’’ properties and at the same time as a protector against nosocomial infections. Klebsiella pneumoniae has developed resistance to antibiotics in the carbapenem antibiotic class, known as carbapenem-resistant K. pneumoniae (CRKP). CRKP is resistant to nearly all antibiotics and can kill up to 50% of infected patients. This work consisted in the development of a washable recycled silk fibroin-based gown covalently linked with an amino acid L-Cysteine(L-Cys), focused on prevention of K. pneumoniae establishment, proliferation and spreading to community, for use under hospital settings. With the growing problem of resistance to antibiotics and few new therapies on the horizon, gowns adsorbed with L-Cys show to function as a barrier to the establishment and proliferation of microorganisms, providing user protection from infectious disease. This gown was knitted at a rectilinear needle loom with a Jersey knit structure. Then it was cross-linked with L-Cys, subjected to laundry, and subsequently characterized by energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, contact angle, free energy of adhesion, scanning electron microscopy and transmission electron microscopy. Results presented a bactericidal effect against K. pneumoniae of 94.92% after three rinses and 88.88% after five washing cycles, with the few adhered bacteria with an altered and compromised morphology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1177/1528083716682919pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7489
dc.language.isoengpt_PT
dc.subjectL-Cysteinept_PT
dc.subjectAntimicrobial-gownpt_PT
dc.subjectNosocomial infectionspt_PT
dc.subjectAminolysispt_PT
dc.subjectKlebsiella pneumoniaept_PT
dc.titleNew garment proposal for prevention of spreading Gram-negative bacteria resistant to carbapenem antibiotic class under hospital settingspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1165pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1152pt_PT
oaire.citation.titleJournal of Industrial Textilespt_PT
oaire.citation.volume47pt_PT
person.familyNameSequeira Nogueira
person.familyNameGomes
person.familyNameGouveia
person.givenNameFrederico Álvaro
person.givenNameAna Paula
person.givenNameIsabel Cristina
person.identifierH-2141-2015
person.identifier626131
person.identifier.ciencia-id7119-F02C-91CE
person.identifier.ciencia-id221C-606F-5072
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.orcid0000-0003-2229-8920
person.identifier.orcid0000-0002-3332-834X
person.identifier.orcid0000-0003-3290-9529
person.identifier.ridK-1651-2014
person.identifier.scopus-author-id56194664600
person.identifier.scopus-author-id24328741500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc4fd84d8-dab6-4f00-ad8c-3f66a733ac3d
relation.isAuthorOfPublicationdaa0e29d-dc97-4e0a-9f76-d0ebbee542a2
relation.isAuthorOfPublicationa2024ec6-6edb-47e5-b8a0-594066a5036c
relation.isAuthorOfPublication.latestForDiscoveryc4fd84d8-dab6-4f00-ad8c-3f66a733ac3d

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