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Authors
Advisor(s)
Abstract(s)
No primeiro capítulo encontra-se a componente de investigação desenvolvida,
intitulada de: “A importância dos testes de suscetibilidade aos antifúngicos”.
Nos últimos anos, os fungos têm surgido cada vez mais como agentes causadores de
infeções invasivas responsáveis por elevada morbilidade e mortalidade.
Apesar do grande arsenal de antifúngicos presentes no mercado, nem todos os
fármacos podem ser utilizados em todos os casos de infeção causada por fungos. Entre outras
causas, está a existência de resistências. Estas foram sem dúvida as grandes impulsionadoras
da contínua evolução dos testes de suscetibilidade aos antifúngicos.
Estes testes indicam a suscetibilidade e/ou resistência de um fungo a um determinado
antifúngico, sendo de extrema importância na orientação do médico quanto ao tratamento a
ministrar no doente.
Os testes de suscetibilidade aos antifúngicos foram desenvolvidos pelo Clinical and
Laboratory Standards Institute e mais tarde, pelo European Committee on Antimicrobial
Susceptibility Testing, tendo sido definidos por estes organismos como métodos padrão. Os
testes comerciais automatizados são comparáveis aos métodos padrão e são os mais utilizados
em laboratórios hospitalares porque são mais adequados à rotina laboratorial.
O objetivo deste trabalho de investigação é constituir um documento com bases
teóricas sólidas que permita, de acordo com a epidemiologia local, estabelecer protocolos de
execução de testes laboratoriais de suscetibilidade aos antifúngicos e a criação de um guia
para a instituição da terapêutica.
No segundo capítulo, por sua vez, encontrar-se-á de forma sucinta, uma descrição da
minha experiência durante o estágio curricular na Farmácia Avenida do Mileu.
Este estágio permite aos estudantes de Ciências Farmacêuticas aplicar alguns dos
conhecimentos adquiridos ao longo do seu percurso académico, permitindo, conhecer o
mundo da Farmácia comunitária enquanto futuros farmacêuticos.
Este mesmo capítulo encontra-se organizado por diferentes partes de modo a
descrever e resumir de forma objetiva todas as experiências vivenciadas.
The first chapter describes the developed research, entitled: “The importance of susceptibility testing to antifungal”. Over the past years, more and more fungi responsible for invasive infections with high morbidity and mortality rates have been identified. Despite of the great number of antifungals available on the market, not all the drugs can be used in all cases of infection. Among other factors, there are fungi that are resistant against certain antifungals. These resistances were undoubtedly the major foster of the ever growing evolution of antifungal susceptibility testing. These tests, which indicate the susceptibility and/or resistance of a fungus to a particular antifungal, are extremely important in aiding the physician on the treatment that is given to the patient. Up to this day, antifungal susceptibility tests were developed by the Clinical and Laboratory Standards Institute and later on by the European Committee on Antimicrobial Susceptibility Testing. These are defined as the standard methods. Automated commercial tests are comparable to standard methods and are often used in hospital laboratories. The goal of these thesis works is to provide a solid theoretical basis document, according to local epidemiology, that allows to establish laboratory tests of antifungal susceptibility, and to create a guide to promote therapeutic protocols. The second chapter, in turn, will briefly describe my experience during the internship at Farmácia Avenida do Mileu. This internship permits the students of pharmaceutical sciences to apply some of the knowledge acquired throughout his academic career, thus allowing them, to experience the world of community pharmacy as future pharmacists. This chapter is organized in different parts in order to describe and summarize all experiences precisely.
The first chapter describes the developed research, entitled: “The importance of susceptibility testing to antifungal”. Over the past years, more and more fungi responsible for invasive infections with high morbidity and mortality rates have been identified. Despite of the great number of antifungals available on the market, not all the drugs can be used in all cases of infection. Among other factors, there are fungi that are resistant against certain antifungals. These resistances were undoubtedly the major foster of the ever growing evolution of antifungal susceptibility testing. These tests, which indicate the susceptibility and/or resistance of a fungus to a particular antifungal, are extremely important in aiding the physician on the treatment that is given to the patient. Up to this day, antifungal susceptibility tests were developed by the Clinical and Laboratory Standards Institute and later on by the European Committee on Antimicrobial Susceptibility Testing. These are defined as the standard methods. Automated commercial tests are comparable to standard methods and are often used in hospital laboratories. The goal of these thesis works is to provide a solid theoretical basis document, according to local epidemiology, that allows to establish laboratory tests of antifungal susceptibility, and to create a guide to promote therapeutic protocols. The second chapter, in turn, will briefly describe my experience during the internship at Farmácia Avenida do Mileu. This internship permits the students of pharmaceutical sciences to apply some of the knowledge acquired throughout his academic career, thus allowing them, to experience the world of community pharmacy as future pharmacists. This chapter is organized in different parts in order to describe and summarize all experiences precisely.
Description
Keywords
Candida Spp Farmácia Comunitária Infeções Fúngicas Invasivas Testes de Suscetibilidade Aos Antifúngicos