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Desenvolvimento e otimização de nanoemulsões catiónicas com Nestorone®
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Abstract(s)
O presente documento foi realizado no âmbito da Unidade Curricular “Estágio” do
Mestrado Integrado em Ciências Farmacêuticas da Universidade da Beira Interior.
Assim, o relatório encontra-se dividido em três capítulos referentes à componente de
Investigação, Farmácia Hospitalar e Farmácia Comunitária, respetivamente.
O primeiro capítulo refere-se ao projeto de investigação desenvolvido no então
denominado “Centro de Investigação em Ciências da Saúde”, agora RISE-Health, UBI,
intitulado “Desenvolvimento e otimização de nanoemulsões catiónicas com
Nestorone®”. O principal objetivo deste trabalho foi otimizar formulações incorporando
Nestorone®, um agonista potente do recetor de progesterona, que parece ter
aplicabilidade em Esclerose Múltipla. Usando uma nanoemulsão previamente
desenvolvida no grupo de investigação, pretendeu-se estudar a influência da
percentagem de lípido catiónico, a temperatura, o modo de preparação e a adição de
fármaco no diâmetro hidrodinâmico médio das gotículas e no índice de polidispersão.
Finalmente, selecionou-se a formulação contendo fármaco com características mais
próximas dos objetivos delineados (tamanho hidrodinâmico médio < 100 nm e índice
de polidispersão < 0,1) que foi testada no modelo MucilAirTM, por outra investigadora.
Este último ensaio revelou uma boa permeação na mucosa nasal, fazendo destas
formulações um candidato para mais estudos in-vitro, em administração nasal e,
possivelmente, oral.
O segundo capítulo refere-se ao estágio que tive oportunidade de realizar na Unidade
Local de Saúde da Cova da Beira, no âmbito da Farmácia Hospitalar. Este decorreu entre
5 de fevereiro e 29 de março de 2024, sob orientação da Dr.ª Maria Olímpia Fonseca.
Neste são descritas as atividades dos diferentes setores da Farmácia Hospitalar desta
instituição: Setor de Aquisição e Logística, Setor de Farmacotecnia, Setor de Dose
Unitária, Setor de Ambulatório e Setor de Ensaios Clínicos. Este estágio permitiu-me
experienciar o papel fundamental do farmacêutico numa vertente mais clínica
caracterizada pela interação multidisciplinar e pelo uso de estratégias como a otimização
da terapêutica e o acompanhamento individualizado dos doentes. Assim, o farmacêutico
hospitalar promove o uso racional de medicamentos dentro e fora da instituição, tendo
em vista a melhoria contínua da qualidade dos cuidados prestados aos utentes.
O terceiro e último capítulo diz respeito ao estágio em Farmácia Comunitária que teve
lugar na Farmácia Sant’Ana, na Covilhã, no período de 1 de abril a 21 de junho de 2024 sob orientação da Dr.ª Paula Goulão Bártolo. Neste são descritas todas as atividades de
uma farmácia comunitária desde a interação farmacêutico-utente e produção de
medicamentos manipulados até a atividades de back-office como a receção de
encomendas e contabilidade. Este estágio permitiu consolidar as minhas competências
técnico-científicas bem como desenvolver e aperfeiçoar as ferramentas de comunicação
e aconselhamento farmacêutico, fundamentais para o estabelecimento de uma relação
próxima entre profissional de saúde-utente. Este contacto pretende o acompanhamento
contínuo dos utentes, promovendo a literacia em saúde, a adesão à terapêutica e,
consequentemente, uma melhoria da qualidade de vida.
This report was produced as part of the “Internship” course of the Integrated Master's Degree in Pharmaceutical Sciences at the University of Beira Interior. The document is divided into three chapters on Research, Hospital Pharmacy and Community Pharmacy, respectively. The first chapter refers to the research project carried out at the then “Health Sciences Research Centre”, now RISE-Health, UBI, entitled “Development and optimization of cationic nanoemulsions with Nestorone®”. The main objective of this work was to optimize formulations incorporating Nestorone®, a potent progesterone receptor agonist, which seems to have potential application in Multiple Sclerosis. Using a nanoemulsion previously developed in the research group, the aim was to study the influence of the percentage of cationic lipid, the temperature, the preparation method and the addition of the drug on the average hydrodynamic diameter of the droplets and the polydispersity index. Finally, the formulation with the drug with characteristics closest to the objectives outlined (z-average < 100 nm and PdI < 0.1) was selected and tested on the MucilAirTM model by another researcher. This last test revealed good permeation in the nasal mucosa, making these formulations a suitable candidate for further in-vivo studies, in nasal and possibly oral administration. The second chapter refers to the internship I had the opportunity to undertake at the Cova da Beira Local Health Unit, within the scope of Hospital Pharmacy. This took place between February 5th and March 29th, 2024, under the guidance of Dr.ª Maria Olímpia Fonseca. It describes the activities of the different sectors of this institution's Hospital Pharmacy: Acquisition and Logistics Sector, Pharmacotechnics Sector, Unit Dose Sector, Ambulatory Sector and Clinical Trials Sector. This internship allowed me to experience the fundamental role of the pharmacist in a clinical context, characterized by multidisciplinary interaction and the use of strategies such as optimizing therapy and individualized patient monitoring. In this way, the hospital pharmacist promotes the rational use of medicines inside and outside the institution, with a focus on continuously improving the quality of care provided to users. The third and last chapter concerns the internship in Community Pharmacy that took place at Farmácia Sant'Ana, in Covilhã, from April 1st to June 21st, 2024, under the guidance of Dr.ª Paula Goulão Bártolo. It describes all the activities of a community pharmacy, from pharmacist-patient interaction and the production of compounded medicines to back-office activities such as receiving parcels and accounting. This internship allowed me to consolidate my technical-scientific skills as well as develop and improve my communication and pharmaceutical counseling tools, which are fundamental for establishing a close relationship between health professional and patient. The aim of this contact is to continuously monitor patients, promoting health literacy, adherence to therapy and, consequently, an improved quality of life.
This report was produced as part of the “Internship” course of the Integrated Master's Degree in Pharmaceutical Sciences at the University of Beira Interior. The document is divided into three chapters on Research, Hospital Pharmacy and Community Pharmacy, respectively. The first chapter refers to the research project carried out at the then “Health Sciences Research Centre”, now RISE-Health, UBI, entitled “Development and optimization of cationic nanoemulsions with Nestorone®”. The main objective of this work was to optimize formulations incorporating Nestorone®, a potent progesterone receptor agonist, which seems to have potential application in Multiple Sclerosis. Using a nanoemulsion previously developed in the research group, the aim was to study the influence of the percentage of cationic lipid, the temperature, the preparation method and the addition of the drug on the average hydrodynamic diameter of the droplets and the polydispersity index. Finally, the formulation with the drug with characteristics closest to the objectives outlined (z-average < 100 nm and PdI < 0.1) was selected and tested on the MucilAirTM model by another researcher. This last test revealed good permeation in the nasal mucosa, making these formulations a suitable candidate for further in-vivo studies, in nasal and possibly oral administration. The second chapter refers to the internship I had the opportunity to undertake at the Cova da Beira Local Health Unit, within the scope of Hospital Pharmacy. This took place between February 5th and March 29th, 2024, under the guidance of Dr.ª Maria Olímpia Fonseca. It describes the activities of the different sectors of this institution's Hospital Pharmacy: Acquisition and Logistics Sector, Pharmacotechnics Sector, Unit Dose Sector, Ambulatory Sector and Clinical Trials Sector. This internship allowed me to experience the fundamental role of the pharmacist in a clinical context, characterized by multidisciplinary interaction and the use of strategies such as optimizing therapy and individualized patient monitoring. In this way, the hospital pharmacist promotes the rational use of medicines inside and outside the institution, with a focus on continuously improving the quality of care provided to users. The third and last chapter concerns the internship in Community Pharmacy that took place at Farmácia Sant'Ana, in Covilhã, from April 1st to June 21st, 2024, under the guidance of Dr.ª Paula Goulão Bártolo. It describes all the activities of a community pharmacy, from pharmacist-patient interaction and the production of compounded medicines to back-office activities such as receiving parcels and accounting. This internship allowed me to consolidate my technical-scientific skills as well as develop and improve my communication and pharmaceutical counseling tools, which are fundamental for establishing a close relationship between health professional and patient. The aim of this contact is to continuously monitor patients, promoting health literacy, adherence to therapy and, consequently, an improved quality of life.
Description
Keywords
Nestorone® Farmácia Comunitária Farmácia Hospitalar Lípido Catiónico Nanoemulsão