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Abstract(s)
O presente trabalho foi desenvolvido no âmbito da unidade curricular “Estágio” em
Ciências Farmacêuticas e está dividido em dois capítulos.
O primeiro capítulo diz respeito ao estágio curricular efetuado na farmácia Matos
Fernandes entre 11 de setembro de 2017 e 11 de janeiro de 2018 sob a supervisão da
diretora técnica a Drª Sara de Jesus Mendes Vidigal. Este capítulo serve para relatar o
dia a dia de uma farmácia comunitária, ou seja, o seu funcionamento, as atividades
realizadas bem como a experiência adquirida durante este período de estágio.
O capítulo segundo descreve o trabalho de investigação realizado sob a orientação da
Profª. Adriana Oliveira dos Santos. Neste estudo tenta-se perceber os avanços relativos
à entrega intranasal de oligonucleótidos. Para tal, foi efetuada uma pesquisa bibliográfica
em que foram incluídos trabalhos relativos à entrega intranasal ao cérebro e excluindo a
entrega local. Foram apenas analisados estudos in vivo e foram excluídos plasmídeos.
Esta é uma área de uma grande especificidade, e de um enorme potencial, traduzido no
aumento de publicações à medida que também a tecnologia é desenvolvida. Também por
essa especificidade e baixo número de artigos publicados, juntamente com uma grande
diversidade de metodologia utilizada, sistemas de entrega e até na opção de espécie a
utilizar como cobaia, é difícil concluir qual a estratégia mais eficaz. É, contudo, de realçar
que alguns autores conseguiram resultados positivos na entrega ao cérebro e eficácia
terapêutica.
The present work was developed as part of the curricular unit “Estágio” in Pharmaceutical Sciences and it is divided in two chapters. The first chapter is about the internship in Matos Fernandes pharmacy, between the 11th September of 2017 and 11th of January of 2018 under the supervision of Drª Sara de Jesus Mendes Vidigal. This chapter describes the daily work in a community pharmacy, how it functions, the performed activities, and the acquired experience during this period of internship. The second chapter describes the research performed under supervision of Profª. Adriana Oliveira dos Santos. This study aimed to characterize the advances of intranasal delivery of oligonucleotides. For such, a bibliographic research was done, in which were include papers concerning the intranasal delivery to the brain and local delivery was excluded. It were only analyzed in vivo studies and plasmids were excluded. This is a subject of great specificity and a huge potential translated in increasing number of publications as the technology, itself, is developed. Also due to that specificity and low number of published articles, together with a great diversity of methodologies, delivery systems, and even animal species, it is difficult to conclude which strategy was more effective. It should be highlighted that some authors accomplished positive results in brain delivery and therapeutic efficacy.
The present work was developed as part of the curricular unit “Estágio” in Pharmaceutical Sciences and it is divided in two chapters. The first chapter is about the internship in Matos Fernandes pharmacy, between the 11th September of 2017 and 11th of January of 2018 under the supervision of Drª Sara de Jesus Mendes Vidigal. This chapter describes the daily work in a community pharmacy, how it functions, the performed activities, and the acquired experience during this period of internship. The second chapter describes the research performed under supervision of Profª. Adriana Oliveira dos Santos. This study aimed to characterize the advances of intranasal delivery of oligonucleotides. For such, a bibliographic research was done, in which were include papers concerning the intranasal delivery to the brain and local delivery was excluded. It were only analyzed in vivo studies and plasmids were excluded. This is a subject of great specificity and a huge potential translated in increasing number of publications as the technology, itself, is developed. Also due to that specificity and low number of published articles, together with a great diversity of methodologies, delivery systems, and even animal species, it is difficult to conclude which strategy was more effective. It should be highlighted that some authors accomplished positive results in brain delivery and therapeutic efficacy.
Description
Keywords
Cérebro Intranasal Nanoparticulas Oligonucleótidos Sirna