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The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens

dc.contributor.authorFigueira, Marília I
dc.contributor.authorCarvalho, Tiago
dc.contributor.authorMonteiro, Joana
dc.contributor.authorCardoso, Henrique J.
dc.contributor.authorCorreia, Sara
dc.contributor.authorVaz, CV
dc.contributor.authorDuarte, Ana Paula
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2025-02-24T15:09:51Z
dc.date.available2025-02-24T15:09:51Z
dc.date.issued2024-07-23
dc.description.abstractThe role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in therapy. However, despite the clinical efficacy in suppressing tumor growth and the panoply of experimental evidence describing its anticarcinogenic effects, estrogens were abolished from PCa treatment because of the adverse secondary effects. Notwithstanding, research work over the years has continued investigating the effects of estrogens, reporting their pros and cons in prostate carcinogenesis. In contrast with the beneficial therapeutic effects, many reports have implicated estrogens in the disruption of prostate cell fate and tissue homeostasis. On the other hand, epidemiological data demonstrating the lower incidence of PCa in Eastern countries associated with a higher consumption of phytoestrogens support the beneficial role of estrogens in counteracting cancer development. Many studies have investigated the effects of phytoestrogens and the underlying mechanisms of action, which may contribute to developing safe estrogen-based anti-PCa therapies. This review compiles the existing data on the anti- and protumorigenic actions of estrogens and summarizes the anticancer effects of several phytoestrogens, highlighting their promising features in PCa treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFigueira, M.I.; Carvalho, T.M.A.; Macário-Monteiro, J.; Cardoso, H.J.; Correia, S.; Vaz, C.V.; Duarte, A.P.; Socorro, S. The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens. Biomedicines 2024, 12, 1636. https://doi.org/10.3390/ biomedicines12081636pt_PT
dc.identifier.doi10.3390/biomedicines12081636pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/15125
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relationCICS-UBI
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/12/8/1636pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectG Protein-Coupled Oestrogen Receptor - GPERpt_PT
dc.subjectCoumestrolpt_PT
dc.subjectDaidzeinpt_PT
dc.subjectEstrogen receptorspt_PT
dc.subjectEstrogenspt_PT
dc.subjectGenisteinpt_PT
dc.subjectPhytoestrogenspt_PT
dc.subjectProstate cancerpt_PT
dc.subjectQuercetinpt_PT
dc.subjectResveratrolpt_PT
dc.titleThe Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleCICS-UBI
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F111351%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F104671%2F2014/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1636pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStreamFARH
person.familyNameFigueira
person.familyNameCarvalho
person.familyNameGomes Araújo Macário Monteiro
person.familyNameCardoso
person.familyNameCorreia
person.familyNameVaz
person.familyNameDuarte
person.familyNameSocorro
person.givenNameMarília
person.givenNameTiago
person.givenNameJoana Filipe
person.givenNameHenrique
person.givenNameSara
person.givenNameCátia
person.givenNameAna Paula
person.givenNameSílvia Cristina da Cruz Marques
person.identifier1255684
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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