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Pharmacological study of several effects of hydralazine in the bisected rat vas deferens
| dc.contributor.author | Verde, Ignacio | |
| dc.contributor.author | Campos-Toimil, Manuel | pt |
| dc.contributor.author | Orallo, Francisco | pt |
| dc.contributor.author | Gil-Longo, José | pt |
| dc.contributor.author | Loza, Isabel | pt |
| dc.contributor.author | Fernandez-Alzueta, Alejandro | pt |
| dc.date.accessioned | 2010-04-28T10:06:46Z | |
| dc.date.available | 2010-04-28T10:06:46Z | |
| dc.date.issued | 1994 | |
| dc.description.abstract | We have studied several effects of hydralazine in the bisected rat vas deferens. Hydralazine produced a shift to the left of the concentration-response curve for noradrenaline, with potentiation of the maximal response in both portions of the vas deferens. In contrast it caused a shift to the right of the concentration-response curve for noradrenaline in preparations pretreated with cocaine (inhibitor of catecholamine neuronal uptake), and of the curve for methoxamine and for CaCl2 (in depolarizing medium with K+ 55 mM), in all cases with depression of the maximal response. Hydralazine enhanced the contractions induced by noradrenaline in Ca2+-free medium, except in the presence of cocaine. It had no effect on [3H]noradrenaline neuronal uptake into noradrenergic neurons of the vas deferens, nor did it affect basal or K+-induced 45Ca2+ uptake. These results suggest that hydralazine potentiates the contractions elicited by noradrenergic by a mechanism other than blockade of the neuronal uptake of this catecholamine. Our results also suggest that the inhibition by hydralazine of the contraction elicited by Ca2+ (in Ca2-free depolarizing high-K+ 55 mM solution) and by methoxamine is not due to an action on voltage-dependent Ca2+ channels, but may reflect an intracellular site of action. | |
| dc.identifier.uri | http://hdl.handle.net/10400.6/544 | |
| dc.language.iso | eng | pt |
| dc.title | Pharmacological study of several effects of hydralazine in the bisected rat vas deferens | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 251:83-90 | pt |
| oaire.citation.title | European Journal of Pharmacology | pt |
| person.familyName | Verde | |
| person.givenName | Ignacio | |
| person.identifier.ciencia-id | D012-1D7C-791A | |
| person.identifier.orcid | 0000-0003-3492-5725 | |
| person.identifier.rid | M-3991-2013 | |
| person.identifier.scopus-author-id | 55913729400 | |
| rcaap.rights | openAccess | pt |
| rcaap.type | article | pt |
| relation.isAuthorOfPublication | bfb58284-b817-4267-9628-8fa150aa681c | |
| relation.isAuthorOfPublication.latestForDiscovery | bfb58284-b817-4267-9628-8fa150aa681c |
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