Browsing by Issue Date, starting with "1994"
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- Pharmacological study of several effects of hydralazine in the bisected rat vas deferensPublication . Verde, Ignacio; Campos-Toimil, Manuel; Orallo, Francisco; Gil-Longo, José; Loza, Isabel; Fernandez-Alzueta, AlejandroWe have studied several effects of hydralazine in the bisected rat vas deferens. Hydralazine produced a shift to the left of the concentration-response curve for noradrenaline, with potentiation of the maximal response in both portions of the vas deferens. In contrast it caused a shift to the right of the concentration-response curve for noradrenaline in preparations pretreated with cocaine (inhibitor of catecholamine neuronal uptake), and of the curve for methoxamine and for CaCl2 (in depolarizing medium with K+ 55 mM), in all cases with depression of the maximal response. Hydralazine enhanced the contractions induced by noradrenaline in Ca2+-free medium, except in the presence of cocaine. It had no effect on [3H]noradrenaline neuronal uptake into noradrenergic neurons of the vas deferens, nor did it affect basal or K+-induced 45Ca2+ uptake. These results suggest that hydralazine potentiates the contractions elicited by noradrenergic by a mechanism other than blockade of the neuronal uptake of this catecholamine. Our results also suggest that the inhibition by hydralazine of the contraction elicited by Ca2+ (in Ca2-free depolarizing high-K+ 55 mM solution) and by methoxamine is not due to an action on voltage-dependent Ca2+ channels, but may reflect an intracellular site of action.
- O Domínio apriorístico da Comunicação na Transformação da Filosofia (K.-O. Apel)Publication . Amaral, AntónioA “novidade” do pensamento apeleano não reside tanto na filiação explícita numa linhagem filosófica cujas raízes mergulham no pensamento de Wittgenstein, Heidegger e Peirce, mas sobretudo no propósito de sondar a possibilidade, a validade e os limites da mediação linguística, em ordem a uma “transformação da filosofia”. De acordo com esse desígnio crítico, trata-se de indagar acerca da consistência das apologias linguisticistas” da “morte da filosofia”, reconduzindo a crítica da linguagem a um vínculo transcendental, constituidor e legitimador da possibilidade do discurso científico e ético. Esta investigação propõe-se dar conta do modo como se opera no pensamento de Apel essa “viragem transcendental” da linguagem, algumas décadas depois de ter sido consumada pela analítica, pela hermenêutica e pela pragmática a “viragem linguística” da filosofia.
- Old and New Élite in a Village of SonderPublication . Schouten, Maria Johanna ChristinaAn analysis of reputation and status in Minahasa (Indonesia) in relation to socio-economic development. Two periods in the economic history of the region of Sonder are distinguished. In the colonial era, it was among the poorest in Minahasa, while after the independence of Indonesia it developed into a «dollar region» thanks to the lucrative clove cultivation. In a case study of a Sonder village, it is shown how in Dutch colonial times the few wealthy villagers were connected with the local administration and school system to become the village élite. Many of their descendants were in the 1980s still well-to-do, but have been matched by some of the «new rich», that is, entrepreneurs of humble descent.