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Cyclooxygenase-2 immunoexpression in breast cancer : progesterone receptor influence

dc.contributor.advisorMoutinho, José Alberto Fonseca
dc.contributor.advisorMuñoz Moreno, Javier
dc.contributor.authorAlmeida, Micaela Carina Pereira
dc.date.accessioned2014-09-23T09:59:58Z
dc.date.available2014-09-23T09:59:58Z
dc.date.issued2010
dc.date.submitted2010
dc.description.abstractIn breast cancer cyclooxygenase-2 expression is related with high local estrogen receptor levels and consequent poor outcomes, but the clinical relevance of cyclooxygenase-2 is still unclear. We analyzed, by immunostaining, cyclooxygenase-2 and progesterone receptor expression in 31 cases of women with invasive ductal carcinoma, from Child and Women department of Cova da Beira Medical Center. Cyclooxygenase-2 and progesterone receptor expression was observed in 64.5% and 54.8% of the tumors, respectively. We verified that tumors with progesterone receptor expression had lower size and the majority of women with these tumors had no axillary node metastasis, when compared to tumors with positive progesterone receptor. Similar results were found when a correlation between progesterone receptor, cyclooxygenase-2 and clinicopathological factors was performed. These results suggest that progesterone receptor has a protective role in breast cancer by inflammatory pathway modulation. COX-2+/PR+ seems to be a marker of better behavior in ductal invasive breast cancer. We speculate if cyclooxygenase-2 determination may have be a clinical usefulness in clinical practice. It’s expected that further studies may clarify this issue.por
dc.identifier.urihttp://hdl.handle.net/10400.6/2311
dc.language.isoengpor
dc.subjectCancro da mamapor
dc.subjectCancro da mama - Ciclooxigenase 2por
dc.subjectCancro da mama - Receptor de progesteronapor
dc.subjectCancro da mama - Receptor de estrogéniopor
dc.titleCyclooxygenase-2 immunoexpression in breast cancer : progesterone receptor influencepor
dc.typemaster thesis
dspace.entity.typePublication
person.familyNamePereira Almeida
person.givenNameMicaela Carina
person.identifier.ciencia-id1412-14A4-3FE6
person.identifier.orcid0000-0002-4280-0765
rcaap.rightsopenAccesspor
rcaap.typemasterThesispor
relation.isAuthorOfPublication34fac911-a93b-480a-8f7d-75edc2afe688
relation.isAuthorOfPublication.latestForDiscovery34fac911-a93b-480a-8f7d-75edc2afe688
thesis.degree.disciplineCiências da Saúdepor
thesis.degree.levelMestrepor
thesis.degree.nameMestrado em Ciências Biomédicaspor

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